Sequoia interpretation: a kind of NAD-plus prescrual can improve the health of mice on a high-fat diet.

In mice, niacinamide can extend health, but not life expectancy.By Sarah J. Mitchell, 0 Michel Bernier, 0 Miguel A. Aon, Sonia Cortassa, Eun Young Kim, Evandro F. Fang, Hector H. Palacios, Ahmed Ali, Ignacio Navas-Enamorado, Andrea Di Francesco, Tamzin A. Kaiser, Tyler B. Waltz, Ning Zhang, James L. Ellis, Peter J. Elliott, David W. Frederick, Vilhelm A. Bohr, Mark S. Schmidt, Charles Brenner, David S. Anthony A. Sauve, Joseph A. Baur, and Rafael de Cabo (Interpreter) Dr. Du Shaokang Peking University is reading the journal Cell Metabolism (Publishing Time) 2018 "Impact Factor" 21.567 (Documentary Interpretation) Niacinamide (NAM) is one of the three niacin adenine dinucleotide (NAD) pre-vitamins, mainly recovered by breaking down NAD in the diet.
in cells, NAM is formed by NAD-consuming enzymes such as sirtuins, CD38, etc.
CD38 is a glycoside hydrolyzed enzyme that is involved in NAD age-related decline and mitochondrial function damage through its ability to regulate SIRT3 activity.
NAD helps maintain mitochondrial health and is essential for tissue health, including nerves and the heart.
studies have shown that adding NR (NAD prebiosis) to the diet can prevent obesity in mice induced by a high-fat diet (HFD), while improving liver function and preventing diabetic neuropathy.
and these NAD preses can help prolong life and reduce metabolic disease.
For example, NR promotes oxidative metabolism by increasing the NAD-plus/NADH ratio and circulating fatty acid levels in muscle, liver, and brown adipose tissue, but little is understood about the effects of high doses of NAM on rodent metabolism, especially in HDD.
images from a web-based study of the effects of slow supplement NAM (62 weeks in total) on the life expectancy and health cycle characteristics of male C57BL/6J mice.
mice were divided into six groups: three in the low-fat diet and three in the high-fat diet, each with a blank control, one with 0.5gNAM/Kg, and one with 1.0gNAM/Kg.
study examined the livers of mice for histological, biotransmissical, etc. to understand the effects of SUPPLEMENT supplementation on liver metabolism in mice fed synthetic low-fat diets (SDs) and high-fat diets (HFDs).
a series of bio-chemical analyses, NAM can be identified as having a potential mechanism to enhance liver glucose treatment and reduce oxidative stress.
in HFD mice, NAM appears to have a greater beneficial effect than in SD, which may provide important clues to its therapeutic potential in the fight against obesity and related diseases.
diagram can be very good performance of the work of this paper, as shown, by adding NAM to HFD mice, accelerate the metabolism and acetylation of NAM, glycogen storage rate has also increased, oxidative stress inflammation reduced.
NAM can prevent fatty liver production in obese mice while improving sugar metabolism.
can be analyzed by histological staining skep, NAM addition reduces morphological changes in the liver due to aging and the HFD diet.
This study is the first to show that chronic supplementation of NAM is well toned and prevents liver fatification caused by diet, while improving glucose metabolism and redox status in the liver of mice, independent of food intake, weight, or body composition.
In HFD-fed mice, NAM restores glycogen deposition levels to the levels observed in the SD feeding group, and NAM's beneficial role in reducing oxidative stress and inflammation may be a factor in combating age and HFD-induced DNA damage.
, as a prelude to NAD plus, the role of niacinamide (NAM) in life expectancy and health cycles is not clear.
article reported on the health breadth indicators of chronic supplement NAM to improve the health of mice without prolonging their lifespan.
the first time that chronic supplementation of NAM is well toned and prevents liver fatification caused by diet.
non-targeted metabolic spectrum analysis of the liver and metabolic influenza analysis of liver-source cells showed that in mice on a high-fat diet (HFD), NAM-mediated glucose stabilization was associated with liver fat degeneration and reduced inflammation.
results showed improvements in the health of HFD mice who supplemented NAM without survival effects.
beneficial role of NAM in reducing oxidative stress and inflammation may be a factor in combating DNA damage caused by aging and HFD.
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( extended reading ) NaDP-nicoamide adenine dinucleotide phosphate (nicotinamide adenine dinucleotide phosphate) abbreviated, once known as triphosphate nicotin nucleotide (TPN) or cohydrogenase II. or oxidizing coenzyme II.
it is a coenzyme, is niacinamide adenine dinucleotide and a phosphate molecule in combination with ester bonds of the substance, widely present in the biological community.
Oxidative Stress - (Oxidative Stress, OS) refers to a state in which oxidation and antioxidant effects in the body are unbalanced, tending to oxidize, leading to inflammation of neutral granulocytes, increased secretion of proteases, and the production of a large number of intermediate oxidation products.
is a negative effect of free fundamentals in the body and is considered an important factor in aging and disease.
male C57BL/6J mice - China's National Rodent Experimental Animal Seed Center Shanghai Branch Center introduced the product line from JAX in 2002.
incidence of breast cancer is low, resistance to radioactive damage, high alcoholism, often used in cancer-causing research.
are commonly used in oncology, physiology, genetics and other aspects of research.
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