Sequoia Interpretation: Supplementing NMN can improve cognitive impairment in old age.

Phenotypes in old mice which nicotinamide mononucleotide improves NMN by regulating CA1 Nampt to improve the cognitive phenotype of the sea masse in older mice (document authors) Sean Johnson, David F. Wozniak and S. Imai. "author:imaishin@wustl.edu Journal" npj Aging and Mechanisms of Disease Release Date 2018.11 (Impact Factor) 5.820 (Documentary Interpretation) Population ageing is a global problem and a topic of great concern to many countries around the world.
, the number of people aged 65 and over is expected to reach nearly 83 million, or more than 20 per cent of the population, by 2050.
the aging of the population is the problem of aging, aging is the decline of a variety of physiological functions, leading to the decline of various tissues, organs, and ultimately lead to a variety of injuries and diseases increased susceptibility.
, the incidence of the central nervous system is higher, cognitive dysfunction is one of its important manifestations.
the main manifestation of our common "Alzheimer's disease" is cognitive dysfunction.
the United States, 22 percent of people over the age of 71 have cognitive impairments.
the high incidence, the importance of prevention and treatment of cognitive impairment can be seen.
how to prevent cognitive dysfunction? First, let's look at how cognitive dysfunction occurs.
found that cognitive dysfunction is closely related to niacin adenine dinucleotide NAD plus.
NAD plus is a classic coenzyme for redox reactions, and levels drop along with the aging process, in part because of a drop in Niacinamide phosphate RNA-based transferase Namct.
niacin is the main prelude to the biosynthetics of mammalian NAD-plus, which is converted by Nampt into niacin mononucleotide NMN, and NMN is further converted into NAD-plus by niacin/niacin single nucleotide adenotide transfer enzyme Nmnat.
Sean Johnson and others have shown that by knocking out Nampt in the CA1 region of young mice, they can lower levels of NAD plus in the body and induce cognitive impairment, and further studies have found that the mechanisms are associated with NMN-NAD-SIRT1-Cask.
suggests that NMN-NAD plus is involved in the progression of aging-related diseases such as cognitive impairment.
(Note: Images from the Internet) So how to prevent cognitive dysfunction ?—— improve NAD-plus levels.
, however, the level of NAD plus in the brain, especially in the sea mass, decreases significantly during aging.
there are five main presupposers known to be used to synthesize NAD plus: tryptophan, nicotine, niacin, niacin, niacin and NMN.
such as Sean Johnson found that long-term NMN supplementation for up to 12 months was effective in alleviating age-related decline in functions such as cognitive impairment.
by researchers such as Xiaonan Wang found that NMN improved cognitive and memory function in Alzheimer's rats by improving energy metabolism and suppressing oxidative stress.
suggest that NMN may be a potential drug to combat cognitive impairment.
the current research on NMN is mostly basic research, still need to be further verified by clinical research.
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: Aging is a global problem and a topic of great concern to many countries around the world.
aging can lead to a decline in the function of the central nervous system, cognitive dysfunction is one of its important manifestations.
the main manifestation of our common "Alzheimer's disease" is cognitive dysfunction.
NAD plus is closely related to cognitive dysfunction.
by knocking out Nampt in the CA1 region of young mice, the level of NAD-plus in the body can be reduced and cognitive dysfunction induced, while supplementation with NAD-plus prescamps can improve cognitive dysfunction in older mice.
suggest that NMN may be a potential drug to combat cognitive impairment.
the current research on NMN is mostly basic research, still need to be further verified by clinical research.
NMN: Niacinamide mononucleotide, is a naturally occurring bioactive nucleotide, which belongs to the category of vitamin B family derivatives and is closely related to immunity and metabolism.
NAD plus: i.e. nicotinamide adenine dinucleotide, is a coenzyme of many dehydrogenases in the body, connecting the triamcinoma acid circulation and respiratory chain, the function of which is to metabolize the hydrogen taken off to the yellow protein.
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