Shanghai experts develop new model of magnetic thermal co-treatment with magnetic heat with magnetic induction programmable ROS

Magnetic field is a safe and time-space-controlled physical meansThe programal regulation of cells based on the coupling of magnetically sensing substances and the magnetic field is expected to provide a simple and effective treatment for tumorsHow to balance the effectiveness and safety of magnetic physiotherapy is a great challenge to its clinical transformationTongji University School of Medicine and the team of Professor Cheng Yu of the affiliated Oriental Hospital combined with the application of high-frequency magnetic heat therapy in clinical practice, found that the micromagnetic force based on ferrite materials and magnetic heat can be co-programmed to regulate the production of tumor cell reactive oxygen (reactive oxygen, ROS), the realization of magnetic thermal double physiotherapy (mechanical-thermal therapy, MTIT), for deep tumor eradication provides a new method of physical and biochemical synergyThe magnetothermal heat therapy (MTIT) regulates the ROS schematics in tumor cells
published online May 9, 2020 in advanced scienceThe first author of the paper is DrWu Tongtong, a doctoral student, and the author of the communication is Professor Cheng Yu of Tongji University School of Medicine and affiliated Oriental Hospitalthis study used 60 nm zinc doped iron oxide nanoblocks as magnetic induction platform, coupled with the precise regulation of the external magnetic field of the double frequency, and metastalevelized the procedural upwardadjustment of reactive oxygen in tumor cells in two stagesThe first stage is ultra-low frequency magnetic increase, magnetic material in 15 Hz rotating magnetic field generated force and torque to destroy the cell subcellular structure, regulate the ROS level in the cell, improve the sensitivity of tumor cells to heat; In animal models of glioma and breast cancer, MTIT has achieved encouraging therapeutic results"The Beginning of Everything, Avenue to Jane"Based on simple magnetic induction materials, through the intelligent regulation of dual-frequency magnetic field, taking into account the depth, effectiveness and safety of tissue penetration, the remote regulation of cell force, heat and biochemical signals can be realized, providing a simpler, more accurate and controllable physical treatment plan for tumor treatmentthe project was strongly supported by Tongji University's Brain and Spinal Spinal Clinical Research Center and affiliated Oriental Hospital, and received funding from the National Natural Science Foundation, the Shanghai Municipal Education Commission's Major Innovation Program, the Central University Fund, Tongji University Education Development Fund, and Shanghai Blue Cross Brain Hospitalsource: specialist