Shanghai Jiaotong University's Wang Gang team reveals the correlation between Alzheimer's and cancer risk in the Chinese population

Alzheimer's disease (AD), commonly known as "Alzheimer's disease", is a serious neurodegenerative disease.
Patients usually suffer from memory decline and weakened learning ability, accompanied by emotional regulation.
Obstacles and loss of athletic ability greatly affect the development of individuals, families and even society
.

Currently, about 50 million people worldwide suffer from Alzheimer's disease
.

As the average life expectancy of human beings increases and the aging society intensifies, the prevalence of Alzheimer's disease is also rising.
It is estimated that by 2050, Alzheimer's patients will increase to more than 150 million
.

With the intensification of population aging, the incidence of chronic non-infectious diseases such as neurodegenerative diseases, cancer, and metabolic syndrome has increased year by year, becoming the main cause of death for the population
.

Alzheimer's disease is the most common neurodegenerative disease, but its exact pathogenesis has not been fully elucidated, and the existing treatments can only partially delay the progression of the disease without reversing the course of the disease, and the effect is not good
.

Cancer is a proliferative disease, which tends to occur in the middle-aged and elderly people, and has a certain similarity with Alzheimer's disease
.

Epidemiological studies based on European and American populations suggest that Alzheimer's disease is negatively correlated with cancer risk, that is, people with Alzheimer's disease have a lower risk of cancer than those with non-Alzheimer's disease
.

The Chinese population and the European and American populations have different genetic backgrounds, life>
.

At present, there is no research to explore the correlation between Alzheimer's disease and cancer risk in the Chinese population
.

Recently, Wang Gang, the chief physician team of the Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, published a titled: Association between Alzheimer's disease and risk of cancer: A retrospective cohort study in the authoritative journal Alzheimer's & Dementia (IF=21.
6) in the field of neurology.
Research papers in Shanghai, China
.

The study focused on the correlation between Alzheimer’s disease and cancer risk in the Chinese population, and initially clarified the relationship between Alzheimer’s disease and cancer, which is negatively correlated with lung cancer, prostate cancer, and testicular cancer.
There is a positive correlation with lymphoma
.

The research results suggest that clinicians need to pay attention to the comorbidity of the elderly in the diagnosis and treatment process; at the same time, the research results also help to further explore the pathogenesis of Alzheimer's disease and find intervention targets
.

Chief physician Wang Gang conducted a large-sample retrospective cohort study (8097 patients with Alzheimer’s disease and 16194 matched non-Alzheimer’s controls) and found that in the Chinese population of Alzheimer’s patients, he suffered from The total risk ratio of various cancers is 0.
822 (95% CI=0.
728-0.
928, P=0.
002)
.

Among them, the risk of three types of cancer is significantly correlated with Alzheimer's disease, namely: lung cancer (HR=0.
656, 95% CI=0.
494-0.
871; P=0.
004), prostate cancer and testicular cancer (HR=0.
414, 95% CI=0.
202- 0.
847; P=0.
016) and lymphoma (HR=2.
202, 95% CI=1.
005- 4.
826; P=0.
049)
.

The research team further discovered that gender, age, and the presence or absence of diabetes have a certain influence on the association between Alzheimer's disease and cancer risk
.

For diabetic patients, there is no obvious correlation between Alzheimer's disease and cancer risk; while in non-diabetic people, there is a certain correlation between the two
.

The study preliminarily clarified that there is a certain correlation between Alzheimer's disease and cancer, which shows a negative correlation with lung, prostate and testicular cancer, and a positive correlation with lymphoma
.

The research results suggest that clinicians need to pay attention to the comorbidities of the elderly in the diagnosis and treatment process; at the same time, the research results also help to further explore the pathogenesis of AD and find intervention targets
.

Ren Rujing, deputy chief physician of the Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Huang Qiang, a master student, and Xu Gang, associate professor of the School of Public Health, Shanghai Jiaotong University, are the co-first authors.
Chief physician Wang Gang and Professor Chen Shengdi are the co-corresponding authors
.

Link to the paper: https://alz-journals.
onlinelibrary.
wiley.
com/doi/10.
1002/alz.
12436 is open for reprinting, welcome to forward to Moments and WeChat groups