Professor Yuan Shen, Director of the Department of Psychiatry, Shanghai Tenth People’s Hospital and Executive Deputy Director of the Institute of Anesthesia and Brain Function, Tongji University School of Medicine, and Professor Xie Zhongcong, Director of the Geriatric Anesthesia Laboratory of the Massachusetts General Hospital of Harvard University in the United States, through a series of in vivo, In vitro experiments have confirmed from multiple levels of molecules, proteins, tissues, etc.
Or increase tumor invasion/metastasis
To this end, the researchers took colon cancer cells as the main research object, and modeled the injection of propofol into the tail vein of mice while injecting colon cancer cells to simulate the contact between propofol and intravascular circulating tumor cells during the clinical perioperative period.
At the same time, the research team used another GABAAR-specific agonist, Muscimol, to pre-treat tumor cells in vitro and then injected them into the body.
Successful adhesion to vascular endothelial cells is a key link in the metastasis of circulating tumor cells
Based on this, the researchers further locked the important target for the development of anti-cancer drugs, and at the same time an important proto-oncogene-Src kinase that mediates cell adhesion
This discovery has very important clinical significance in the fields of anesthesiology, oncology and surgery
Related paper information: http://doi.
http://doi.
org/10.
1002/advs.
202102079
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