Significant progress has been made in the analysis and lineage division of the new coronavirus genome

Science and Technology Daily Kunming, April 5 (Reporter Zhao Hanbin) reporter on the 5th from China Kexue Yuan Kunming Institute of Zoology, was informed that the cooperation with the domestic research institutions to resolve the evolution of novel coronavirus genome, presents a hierarchical structure The pedigree and sub-pedigree division system.

As the number of infections increases, the new coronavirus will rapidly develop many different strains.

In Keyuan Kunming Institute of Zoology, Lv Xuemei, Zhang Yaping research group with the College of Life Sciences, Peking University research group Lu Jian, Chinese Center for Disease Control and Prevention Tan Wenjie Task Force and other team analyzed single nucleotide variations 121,618 high-quality viral genome , Screened out 201 representative single-nucleotide variants, and then divided 130 sub-lineages level by level, and drawn a complete haplotype network diagram reflecting the genetic relationship between each lineage.

In order to clarify whether the prevalence of different sub-lineage viruses is different, the research team divided the 119,168 high-quality virus genomes with specific sampling time information according to the lineage division system.

The research team also collected domestic imported case data from April 2020 to January 2021, and displayed it on the pedigree system haplotype network, which can provide inferred information for the source of imported cases.

This study includes most of the current mutations in the new crown genome, and sorts out their lineage relationships, clarifies the temporal and spatial distribution of each lineage, and builds a general framework for the evolution of the new crown virus, which is useful for understanding the law of pathogen variation and tracking the epidemiology of the new crown.