Significant progress in the study of drug-resistant plasmids

The reporter learned from South China Agricultural University that the postdoctoral fellow Yang Jun, under the guidance of Professor Liu Jianhua of the School of Veterinary Medicine and Professor Wang Haihong of the School of Life Sciences, has made important progress in the research of drug-resistant plasmids, and published the relevant research results in Nucleic Acid Research as the first author.

Colistin is the last line of defense medicine in the clinical fight against multi-drug resistant bacteria infection.

The Ministry of Agriculture and Rural Affairs of China issued a notice prohibiting the use of colistin sulfate for growth promotion in food animals in July 2016.

This is the first study IncI2 pHNSHP45 plasmid encoding ProQ / FinO family proteins PcnR played a key role in the regulation of adaptive plasmid, PCNR missing IncI2 type mcr-1 plasmid host strain will cause great adaptability price.

Yang Jun said that the study not only broadened our understanding of the functions of the ProQ/FinO family proteins encoded by plasmids, but also revealed the necessary conditions for the retention of mcr-1 plasmids and explained mcr-1 and its plasmids after the adjustment of the colistin use policy.

It is worth mentioning that the South China Agricultural University veterinary post-doctoral mobile station was established in 2003 and currently has 39 mobile station tutors.

Related paper information: org/10.