Single-cell encapsulation technology that doesn't hurt cells: Make industrial microbes healthier and more dry.

The new technology encapsulates cyanobacteria with the egg yolk shell structure of "nano shell space cell" to ensure the activity and stability of industrial cells.human beings have used microorganisms for hundreds of years.since industrialization, microorganisms have shown great economic value in bioenergy and pharmaceutical industries.however, in industrial reaction vessels, the biological activity and stability of microorganisms are often low, and the separation of products is facing great challenges.one of the effective solutions is cell packaging technology, which is to wrap cells with shell materials to make them more adaptable to the industrial environment.however, due to the direct contact between the shell material and the cells and the low permeability, cell encapsulation often leads to apoptosis, which greatly shortens the survival time of microbial cells.in response to the above problems, the researchers reported a single cell packaging technology based on cyanobacteria in the National Science Review (NSR).in this technology, nano assembly shell does not directly contact with cells, and has good connectivity, and can realize molecular recognition.the researchers involved in this work include: academician Su Baolian and Professor Yang Xiaoyu from the life composite Laboratory of Wuhan University of technology; Professor Henk J. busscher of Groningen University in the Netherlands; Professor n ü Elle ninane of Namur University in Belgium; gustaaf van, University of Antwerp and nano micro center of Wuhan University of technology Professor tendeloo and Dr. tawfique Hasan of Cambridge University, UK; the first author of the paper is Dr. Wang Li.protamine is used as an electrostatic template to induce the ordered self-assembly of nano silica sol to form a uniform and controllable cell shell.using the characteristics of protamine cell internalization, a layer of gap was formed between the cell shell and cyanobacteria to form a "nano shell space cell" yolk shell structure.this new yolk shell structure not only ensures the long-term survival of cyanobacteria, but also improves its photosynthetic activity and tolerance to extreme survival conditions (such as high temperature, organic oil phase, toxic macromolecular environment, antibiotic environment, etc.).in addition, by adjusting the self-assembly of the sol, the pore size and thickness of the cell shell can be precisely controlled, and the continuity of the cell shell can be ensured. A series of new functions can be introduced to realize specific molecular recognition.this new type of single cell packaging technology can effectively improve the cell activity, stability and functionality of cyanobacteria, so as to ensure the comprehensive application of the microorganism.Article Information: [click the link below or "read the original text" to get the full text] single cell York shell nanoencapsulation for long-term viability with size dependent permeability and molecular recognition