Skin stem cell exercise promotes skin regeneration

Researchers at Tokyo Medical and Dental University (TMDU) have discovered that the movement of skin stem cells can help skin regeneration

Tokyo, Japan-Although it is sometimes difficult to accept, as we age, many things in our body will change

In a study published this month in the Journal of Cell Biology, researchers from Tokyo Medical and Dental University (TMDU) revealed that the ability of skin stem cells to repair the skin after injury may be related to their The ability to move to the injured area is related

Skin stem cells, also known as keratinocyte stem cells, are responsible for skin regeneration and wound healing through a process called re-epithelialization

In order to understand the mechanism behind the decline in the vitality of senescent stem cells, the researchers compared the wound healing and proliferation capabilities of skin stem cells in young mice (12 weeks old) and old mice (19-25 months old)

Interestingly, COL17A1 coordinates the movement of skin stem cells to the direction of injury by regulating the intracellular actin and keratin filament network

With age, the decline of skin wound healing ability is related to the development of so-called chronic non-healing diseases, such as diabetic ulcers and pressure sores

The article “EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis” was published in theJournal of Cell Biologyatdoi.