Slc12a8 transport protein: Discover a new path for cell fuel delivery.

A transporter protein called Slc12a8 plays an important role in the cell energy supply chain, delivering fuel needed for cell metabolism directly into cells, researchers at the University of Washington School of Medicine said in a paper published Wednesday in the journal Nature Metabolism.
researchers say the discovery of a new pathway to cell fuel delivery could help shed light on the human aging process and the accompanying pathology of chronic diseases, which in turn could help develop new therapeutic drugs that reduce the adverse effects of years on the human body.
in a variety of cellular metabolic reactions, the niacinamide adenine dinucleotide (NAD) molecules play an important role and are an important support for cell vitality.
But as we age, NAD levels decrease and cell metabolism is affected.
Although scientists have discovered that cell production of NAD is a precursor molecule that starts with a mononucleotide (NMN) called niacinamide, it is not clear how this precursor molecule enters the cell and processes it into NAD.
, researchers at the University of Washington have found the answer to the puzzle.
they eventually discovered the delivery mechanism of NMN after several experiments in cells and mice.
studies have shown that the Slc12a8 protein transports NMN directly into cells with the help of sodium ions and works quickly for NAD production.
when NAD levels drop, cells also increase the expression of the Slc12a8 gene, increasing their ability to transport NMN.
researchers say the discovery of the NMN transport mechanism is important and could help scientists find ways to increase the supply of energy to senescent cells.
past studies have shown that giving NMN to older mice is beneficial to their overall metabolism and has a positive effect on skeletal muscle, liver function, bone density, eye function, insulin sensitivity, immune function, etc.
new study suggests that a combination of SUPPLEMENTING NMN and stimulating MMN transport proteins may help older people maintain cellular energy and alleviate chronic aging-related chronic symptoms.
, researchers have identified small molecules that enhance the function of NMN transport proteins and have partnered with pharmaceutical companies to develop new treatments for chronic diseases in old age.
editor-in-chief circle dating is not a dream from ancient times, but most scientists believe that, due to the limitations of the underlying biological mechanism, humanbeing is unlikely to live over 130 years old, the dream will be crushed.
but the rapid progress of aging science in recent years has provided many important enlightenments for the extension of life.
some key substances and signals that can significantly delay or even partially reverse the aging of nematodes and mice.
hope that these discoveries early transformation, give us a "not old sandain" it.
Source: Science Daily.