Sleep deprivation affects microRNA function in the body, which can damage cardiovascular disease.

The findings may help researchers develop new non-invasive tests for sleep-deprived patients to help monitor their healthResearcher Christopher DeSouza said: 'In this study, we shed light on a new potential mechanism for how sleep affects heart health and the physiological health of the body as a wholeAlthough the American Heart Association recommends that people get 7-9 hours of sleep a night, about 40 percent of the population is not up to standard, and overall, the average American sleep has dropped from 9 hours a night to 6.8 hours a night over the past centuryin a separate study,researchers found that adult men who slept six hours a night had abnormal vascular endothelial cells, and that their arteries did not expand and contract normally in people who slept enough, but they did not know the mechanismbehind the abnormalityMicroRNAs, a small molecule that inhibits the expression of specific protein genes in cells, has been extensively studied by researchers to illustrate the function of microRNAs molecules in the cardiovascular system and their effects on the body's cardiovascular health, and researchers are developing microRNA markers that can correct damage in patients' bodies, including cancerresearchers say it's like a cell brake, and if the body lacks beneficial microRNAs, it may have a significant impact on cell healthFor the first time, researchers analyzed the effects of lack of sleep on the body's circulatory microRNA, and analyzed blood samples from 24 healthy men and women between the ages of 44 and 62 who filled out questionnaires about their sleep habits, with half sleeping 7-8.5 hours a night and the other 5-6.8 hours a nightresearchers measured the expression levels of nine microRNAs in the participants' bodies, which were previously thought to be directly related to inflammation, immune response, or cardiovascular healthThe researchers found that levels of miR-125A, miR-126 and miR-146a circulating in the body decreased by 40-60% compared to sleep-deprived participants, who were thought to inhibit the expression of inflammatory proteins'It's not clear why seven or eight hours of sleep is the best time, ' says De Souza, 'but it sounds reasonable that humans need at least seven hours of sleep a night on average to maintain important physiological regulatory mechanisms, such as microRNAcurrently researchers are studying whether restoring sleep habits can restore the health levels of microRNA in the body, which appears to be a marker of cardiovascular disease in sleep-deprived people, helping clinicians obtain important information about patients through blood tests, rather than invasive meansSo we don't underestimate the importance of getting a good night's sleepOrigins: Jamie GHijmans, Ma'ayan Levy, Vinicius Garcia, et alRye sleep is amiama a pro-atherogenic circulating microRNA signatureAl-Physiology, 2019; DOI: 10.1113/EP087469