Small molecule drug ceftazidime can inhibit new coronavirus infection in vitro

SARS-CoV-2 mediates viral infection through the binding of its surface S protein and host cell receptor ACE2

In summary, the study found that the antibiotic ceftazidime can specifically bind to the SARS-CoV-2 S protein and block its interaction with ACE2, thereby effectively inhibiting the infection of host cells by the new coronavirus in vitro

Researcher Chen Jianfeng from the Center of Molecular Cell Excellence is the corresponding author of the paper, researcher Li Guohui from Dalian Institute of Chemical Physics, Chinese Academy of Sciences is the co-corresponding author, Associate Researcher Lin Changdong, PhD student Li Yue, and Associate Researcher Zhang Yuebin from Dalian Institute of Chemical Physics The first author

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Ceftazidime blocks the interaction between S protein and ACE2 by binding to S protein, acting as a protective shield to protect host cells from SARS-CoV-2 infection