Some problems needing attention in the steps of Sihuan freeze-drying pharmaceutical freeze-drying machine

The physical, chemical and biological states of the medicines lyophilized by the four-ring freeze-drying machine are basically unchanged, the volatile components and the heat-denatured nutrients in the medicines have little loss, and the lyophilized substances are porous
.

It is suitable for the research and development and production of various heat-sensitive pharmaceutical and biological products
.

The various steps in the application of freeze-drying technology of Sihuan freeze-drying pharmaceutical freeze-drying machine are closely related, and the process is easily affected by other factors
.

Therefore, effective measures should be taken to eliminate the interference of other factors in practical application to ensure the quality of drugs
.

Here are some points to be aware of for the different steps in lyophilization applications
.

1.
Preparation of medicines The preparation of medicines should be selected in combination with the implementation standards of freeze-drying technology to avoid damage to medicines during the freeze-drying process
.

Carefully check the parameters used for freeze-drying medicines, and apply freeze-drying in a responsible attitude to the patient
.

2.
Pre-freezing of medicines Pre-freezing of medicines is the first step of freeze-drying medicines
.

The main purpose of this step is to solidify the physicochemical bound water and free water existing in the medicine, while ensuring that the material structure of the medicine is not damaged
.

When pre-freezing the drug, it should be carried out in strict accordance with the pre-freezing operation specifications, otherwise the quality of the pre-freezing is not good, and the drug will not be frozen, which will affect the size and shape of the ice crystals during the pre-freezing process, which will affect the next freeze-drying step.
, and even lead to freeze-drying failure
.

 　　At present, the pre-freezing treatment methods are mainly divided into two categories: quick-freezing and slow-freezing
.

Among them, slow freezing is placed on the quality of freezing, and quick freezing reflects the effective control of the efficiency and time of drug freezing
.

It can be seen that there are significant differences between the two methods, and each has its own advantages
.

In addition, during the pre-freezing process, attention should be paid to the crystallization state, and the machine should be operated flexibly to keep the crystallization in a normal state
.

The operation requirements of this process are high, and experienced technicians should be responsible for this link
.

 　　3.
Sublimation drying The freeze-drying step is to remove the natural moisture crystallized in the medicine
.

This step lies in the control of vacuum degree and temperature, and in order to accurately grasp the amount of water removed, the specific heat capacity of the medicine in different steps should be calculated, so as to achieve a better drying effect
.

 　　4.
Analytical drying The freeze-drying step is to remove the structural water in the medicine
.

After a lot of practice, it has been proved that the length of time required for the analytical drying process has a great relationship with the working performance of the freeze dryer, so it should be grasped in this step
.

 　　5.
Sealed preservation This is the last step in the treatment of drug freeze-drying technology, and it is also a final link that needs to be taken seriously.
It must not be sloppy
.