Stroke: The foramen ovale is not closed, after closing it can reduce the risk of recurrence of stroke

Foramen ovale (PFO) and cryptogenic young patients of stroke -related, may be due to allow systemic venous thrombosis embolism through the atrial septum, into the left atrium and systemic arterial circulation

Until there is definite evidence to prove its efficacy, transcatheter closure of PFO to eradicate right-to-left shunt is considered to be an intervention to reduce the risk of recurrence in patients with presumed PFO-related stroke, and transcatheter closure devices have been used in clinical practice

In order to confirm or refute the benefits of PFO occlusion, some randomized trials have been conducted.

However, this approach increases the risk of bias and may undermine trust in research conclusions

The change in infarct volume from baseline to follow-up MRI is an objective result that can provide additional support for the important findings of this clinical trial

They performed a blind assessment of the presence, location, and volume of diffusion-weighted imaging of recurrent clinical strokes or new infarcts (>3 mm) of T2/FLAIR, from baseline to 2-year follow-up MRI, comparing block therapy and medication alone Treatment

At follow-up, 18/383 (4.

Compared with drug-treated patients, closed patients had fewer clinical strokes, 5 cases (1.

There was no difference in the number, volume, and distribution of new infarcts compared with patients treated with medication alone