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Click the blue text above to follow a new analysis of our data on U.
S.
military recruits showing that multiple sclerosis (MS), a disease of unknown etiology, is thought to be a complication of Epstein-Barr virus (EBV) infection
.
Multiple sclerosis is a chronic demyelinating disease of the central nervous system
.
The underlying cause of the disease is unknown, but the Epstein-Barr virus is thought to be the culprit
.
However, most people infected with this common virus do not develop multiple sclerosis, and it is not feasible to directly demonstrate the cause of the disease in humans
.
By using data from more than 10 million U.
S.
military recruits monitored over 20 years, 955 of whom were diagnosed with MS while serving, Kjetil Bjornevik et al tested the hypothesis that MS is caused by EBV
.
They found that individuals who were otherwise EBV-negative had a 32-fold increased risk of developing MS following EBV infection
.
"These findings cannot be explained by any of the known risk factors and propose that EBV is a major cause of MS," the authors said,
noting
that one of the most effective treatments for MS is anti-CD20 monoclonal antibodies
.
They say targeting EBV directly may have major advantages over anti-CD20-based therapies, which must be administered by intravenous infusion and may increase the risk of infection
.
Welcome to the official public account of Science and click "Read the original text" below to access the English original text for this issue of Science to light up your reading!
S.
military recruits showing that multiple sclerosis (MS), a disease of unknown etiology, is thought to be a complication of Epstein-Barr virus (EBV) infection
.
Multiple sclerosis is a chronic demyelinating disease of the central nervous system
.
The underlying cause of the disease is unknown, but the Epstein-Barr virus is thought to be the culprit
.
However, most people infected with this common virus do not develop multiple sclerosis, and it is not feasible to directly demonstrate the cause of the disease in humans
.
By using data from more than 10 million U.
S.
military recruits monitored over 20 years, 955 of whom were diagnosed with MS while serving, Kjetil Bjornevik et al tested the hypothesis that MS is caused by EBV
.
They found that individuals who were otherwise EBV-negative had a 32-fold increased risk of developing MS following EBV infection
.
"These findings cannot be explained by any of the known risk factors and propose that EBV is a major cause of MS," the authors said,
noting
that one of the most effective treatments for MS is anti-CD20 monoclonal antibodies
.
They say targeting EBV directly may have major advantages over anti-CD20-based therapies, which must be administered by intravenous infusion and may increase the risk of infection
.
Welcome to the official public account of Science and click "Read the original text" below to access the English original text for this issue of Science to light up your reading!
