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Today, "Nature" magazine has accelerated the publication of an important paper-a research team led by many Chinese scientists has designed a new IgM antibody therapy, which is 240 times more effective than traditional IgG antibody therapy! It can also bring a powerful neutralizing ability to the multiple variants of new coronaviruses that have appeared all over the world.
The researchers pointed out in the paper that almost all antibodies currently used to neutralize the new coronavirus are IgG.
In addition to IgG, there are many different types of antibodies, among which IgM and IgA1 are antibodies that can fight pathogens in the first line of mucosal tissue.
▲Schematic diagram of the structure of IgG, IgA1 and IgM antibodies (picture source: reference [1])
In this paper, the researchers designed human IgM and IgA1 therapies based on six monoclonal antibodies that can recognize different epitopes of the new coronavirus receptor binding domain (RBD).
First, the team confirmed that IgM-14 does have a stronger inhibitory ability.
▲A nasal administration allows IgM therapy to be enriched in the nasal cavity and lungs (picture source: reference [1])
Later, the scientists evaluated the possibility of IgM-14 being administered through the respiratory tract.
Finally, the research team used nasal administration to evaluate the actual protective effect of IgM-14 on mice.
▲For the variant new coronavirus, IgM-14 (red) can also show a better neutralization effect (picture source: reference [1])
Taken together, the study shows that the designed IgM can become a potential neutralizing therapy and protect a wide range of new coronaviruses.
Reference materials:
[1] Ku, Z.
[2] IGM Biosciences Announces Expansion of IgM Platform into Infectious Diseases, Publication of Preclinical Data in Nature Demonstrating Engineered IgM Antibody Antiviral Activity for the Treatment and Prevention of COVID-19, Retrieved June 3, 2021, from https:// .
