Studies in Taiwan have found that antimicrobial peptides of grouper can replace traditional antibiotics

Professor Wu zhangzhe, Department of food science, National Taiwan Ocean University, cooperated with Chen Zhiyi, associate researcher of Linhai research station, Institute of cell and individual biology, Central Research Institute, to carry out the latest research and found that the antimicrobial peptide selected and synthesized from grouper has very good bactericidal effect and can replace traditional antibiotics Traditional antibiotics can not kill drug-resistant bacteria, resulting in drug-resistant bacteria infection patients, faced with the dilemma of no medicine Dr Huang Hanning, Department of food science, Haida, member of the research team, found that epiecidin-1 can promote wound healing, angiogenesis, inhibit the number of bacteria in the blood, reduce the expression of immune inflammatory genes on the skin of burned mice infected with drug-resistant bacteria Moreover, after the mice are infected with drug-resistant bacteria, treatment with epiecidin-1 can achieve 100% survival rate, which can be widely applied in the future For medical use, the research results have been published in the first international journal in the field of biomedical materials According to Professor Wu zhangzhe, antimicrobial peptides have antibacterial and anticancer properties and regulate the signal transmission of the host, which is a hot research topic recently The team used epinecidin-1, which was found in grouper grouper, to make the burn dressing Epinecidin-1 is a positive antibacterial peptide composed of 67 amino acids It has broad antibacterial activity and is not easy to produce resistant strains It is not affected by traditional antibiotic resistant mutants In animal experiments, it has a very good protective effect on the skin of injured mice infected with resistant Staphylococcus aureus Chen Zhiyi, an associate researcher, said that epinecidin-1, an antimicrobial peptide, is a highly alkaline molecule in the head, kidney, small intestine and skin of grouper, which contains a large number of basic amino acids and hydrophobic amino acids, forming a positive structure This kind of antibacterial peptide mainly uses a large number of positive charges and negative charges of bacterial cell membrane to combine with each other, and then produces perforation, penetration, disruption and other attacks on bacterial cell membrane, which makes bacterial cell membrane rupture and die The team found that in addition to being resistant to bacteria, antimicrobial peptides also have the function of inhibiting cancer and other tumors In addition, gene therapy and feed filling can enhance the immune ability and survival rate of aquaculture organisms In the future, it can be widely used in all kinds of fish diseases, veterinarians, human medicine and medical purposes, with very high application value Antimicrobial peptide is a kind of micro substance in organism, which has the characteristics of rapid generation and diffusion It is mainly to help organism fight against harmful substances in vivo According to the literature, more than 3000 kinds of antimicrobial peptides have been found They have the functions of permeating bacterial cell membrane, perforating, interfering with bacterial proliferation and promoting wound healing.