Study finds CPEB3 protein prolongs memory shelf life by stimulating neurons

Researchers have mapped the molecular mechanisms of the brain to maintain long-term memory by looking at neuronal activity extracted from the brain, neuroscientists at Columbia University said in a paper published in the Proceedings of the National Academy of SciencesThe researchers outlined how the CPEB3 protein stimulates neurons to store time-tested memoriesfindings offer a new perspective on one of the most common and basic molecular functions of the brainIt provides a new target for degenerative neurological disorders characterized by memory lossmemory is the crystallization of neuronal "love"the production of memory is wonderful, even a fleeting short impression is the "love" collision between neuronsMemory is born when two neurons extend small branches (axons) to connect to each otherWe call these connections synapses, the bonds of neuronal "love." However, some close connections, memory can stand the test of the years;the link between neurons Picture: Wikipedia2015, Nobel Prize winner Eric Kandel and his team found in mice that there is a protein called CPEB3 in synapses that not only appears when memories are formed, but also when they recall the pastDr Luana Fioriti, senior author of thepaper, said: "When we inhibit edgy cpEB3 protein in the brains of mice, mice can still form new memories, but these memories are not preserved intactIf cpEB3 is completely removed, the synapses break and the memory disappearsThe "love" bond betweenneurons is reinforcedresearchers have found that CPEB3 protein is regularly produced in the hippocampus neurons that control memoryEven more amazing, once CPEB3 is produced, it is transferred to the P body, which is like an isolation chamber that allows CPEB3 to sleep and ready to be used at any time P body does not have the same physical barrier as cell membranes to hold CPEB3 Because the Density of the P body is greater than that of the surrounding environment, this density difference holds the substances in the P body together, leaving CPEB3 inside the cell rather than escaping to other parts of the cell once the P body fills the CPEB3, it leaves the center of the neuron and moves along its branches toward the synapse When the mice began to form memories, the P body dissolves CPEB3 is released into synapses to help create memories Over time, as more CPEB3 is released, the link between neurons strengthens This alters the anatomy of neurons, which stabilizes memory researchers at Columbia University have found that CPEB3 does not enter the P body on its own, it requires a route called SUMO protein This process is called SUMOylation conclusion
this study provides insight into neurodegenerative diseases characterized by memory loss, in addition to revealing the formation and disappearance of memories Studies have demonstrated the importance of CPEB3 in memory storage, and CPEB3 protein sits in the human brain, suggesting that CPEB3 protein may be a potential target for neurodegenerative diseases Dr Fioriti said: "Our results highlight the key role of protein synthesis in preserving memory This is very important for the study of Alzheimer's disease By continuing our in-depth study, we can one day develop useful ways to promote CPEB3 to prevent synaptic degeneration and thus slow memory loss "
1' Pinpointing how cells long-reeds 2 s U.S scientist s how how brain cells checkes in mice study original title: PNAS: Grab this protein! Extending the shelf life of memory depends on it...