Study: Gut microbes may be key to unlocking anxiety

According to foreign media reports, a mouse study showed that the genetic part of anxiety is mediated by the gut microbiota. Anxiety disorders are already the most common mental illness in many countries, including the United States. During the new pandemic, the prevalence of anxiety disorders has risen sharply. Research led by Berkeley Laboratories in the field of biological sciences and published in the "Scientific Reports" research provides evidence that taking care of our gut microbiota may help reduce some anxiety. The research team used a genetically heterogeneous mouse lineage called collaborative crossover (CC) to probe the connection between genes, gut microbial composition, and anxiety-like behaviors. They first classified 445 mice across the 30CC strain, and classified them into high anxiety and low anxiety based on their behavior in the light/dark box experiment. The light/dark box has two compartments, one is transparent and illuminated, and the other is black and unilluminated, connected by an opening. To what extent rodents’ natural aversion to bright, open spaces has replaced their instinct to explore new environments, roughly equivalent to high (or low) anxiety. The researchers then performed a genome-wide association study (GWAS) analysis. They compared high- and low-anxiety mice, and also analyzed and compared the gut microbiome composition of high- and low-anxiety animals. As a result, they discovered specific gene variants and gut microbial families related to anxiety behavior, including host genes that indirectly affect anxiety by regulating the abundance of specific microbes in the gut. Antoine Snijders, a scientist in the Biological Systems and Engineering Division and co-lead author of the paper, said: "We hope that this study will provide information for future studies to evaluate anxiety treatments that take the host genome and microbiome into account. "      Disclaimer: This article only represents the author's personal views and has nothing to do with China Probiotics. com. The originality and the text and content stated in the article have not been verified by this site. This site does not make any guarantee or commitment to the authenticity, completeness, and timeliness of this article, all or part of the content, and the text. Please readers for reference only, and please Verify the relevant content yourself.      Copyright Notice    1. Some of the reprinted articles on this site are not original, and the copyright and liability belong to the original author. 2. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and clearly indicate the source and author. Media or individuals who do not want to be reprinted can contact us for infringement information that can provide sufficient evidence , Bio149 will be deleted within 12 hours after confirmation. 3. Users are welcome to post original articles to 86371366@qq. com, and publish them to the homepage after review. The copyright and liability belong to the sender.

　　According to foreign media reports, a mouse study showed that the genetic part of anxiety is mediated by the gut microbiota.
Anxiety disorders are already the most common mental illness in many countries, including the United States.
During the new pandemic, the prevalence of anxiety disorders has risen sharply.
Research led by Berkeley Laboratories in the field of biological sciences and published in the "Scientific Reports" research provides evidence that taking care of our gut microbiota may help reduce some anxiety.
　　The research team used a genetically heterogeneous mouse lineage called collaborative crossover (CC) to probe the connection between genes, gut microbial composition, and anxiety-like behaviors.
They first classified 445 mice across the 30CC strain, and classified them into high anxiety and low anxiety based on their behavior in the light/dark box experiment.
The light/dark box has two compartments, one is transparent and illuminated, and the other is black and unilluminated, connected by an opening.
To what extent rodents’ natural aversion to bright, open spaces has replaced their instinct to explore new environments, roughly equivalent to high (or low) anxiety.
　　The researchers then performed a genome-wide association study (GWAS) analysis.
They compared high- and low-anxiety mice, and also analyzed and compared the gut microbiome composition of high- and low-anxiety animals.
As a result, they discovered specific gene variants and gut microbial families related to anxiety behavior, including host genes that indirectly affect anxiety by regulating the abundance of specific microbes in the gut.
　　Antoine Snijders, a scientist in the Biological Systems and Engineering Division and co-lead author of the paper, said: "We hope that this study will provide information for future studies to evaluate anxiety treatments that take the host genome and microbiome into account.
"

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　　According to foreign media reports, a mouse study showed that the genetic part of anxiety is mediated by the gut microbiota.
Anxiety disorders are already the most common mental illness in many countries, including the United States.
During the new pandemic, the prevalence of anxiety disorders has risen sharply.
Research led by Berkeley Laboratories in the field of biological sciences and published in the "Scientific Reports" research provides evidence that taking care of our gut microbiota may help reduce some anxiety.
　　The research team used a genetically heterogeneous mouse lineage called collaborative crossover (CC) to probe the connection between genes, gut microbial composition, and anxiety-like behaviors.
They first classified 445 mice across the 30CC strain, and classified them into high anxiety and low anxiety based on their behavior in the light/dark box experiment.
The light/dark box has two compartments, one is transparent and illuminated, and the other is black and unilluminated, connected by an opening.
To what extent rodents’ natural aversion to bright, open spaces has replaced their instinct to explore new environments, roughly equivalent to high (or low) anxiety.
　　The researchers then performed a genome-wide association study (GWAS) analysis.
They compared high- and low-anxiety mice, and also analyzed and compared the gut microbiome composition of high- and low-anxiety animals.
As a result, they discovered specific gene variants and gut microbial families related to anxiety behavior, including host genes that indirectly affect anxiety by regulating the abundance of specific microbes in the gut.
　　Antoine Snijders, a scientist in the Biological Systems and Engineering Division and co-lead author of the paper, said: "We hope that this study will provide information for future studies to evaluate anxiety treatments that take the host genome and microbiome into account.
"

---

　　According to foreign media reports, a mouse study showed that the genetic part of anxiety is mediated by the gut microbiota.
Anxiety disorders are already the most common mental illness in many countries, including the United States.
During the new pandemic, the prevalence of anxiety disorders has risen sharply.
Research led by Berkeley Laboratories in the field of biological sciences and published in the "Scientific Reports" research provides evidence that taking care of our gut microbiota may help reduce some anxiety.
　　The research team used a genetically heterogeneous mouse lineage called collaborative crossover (CC) to probe the connection between genes, gut microbial composition, and anxiety-like behaviors.
They first classified 445 mice across the 30CC strain, and classified them into high anxiety and low anxiety based on their behavior in the light/dark box experiment.
The light/dark box has two compartments, one is transparent and illuminated, and the other is black and unilluminated, connected by an opening.
To what extent rodents’ natural aversion to bright, open spaces has replaced their instinct to explore new environments, roughly equivalent to high (or low) anxiety.
　　The researchers then performed a genome-wide association study (GWAS) analysis.
They compared high- and low-anxiety mice, and also analyzed and compared the gut microbiome composition of high- and low-anxiety animals.
As a result, they discovered specific gene variants and gut microbial families related to anxiety behavior, including host genes that indirectly affect anxiety by regulating the abundance of specific microbes in the gut.
　　Antoine Snijders, a scientist in the Biological Systems and Engineering Division and co-lead author of the paper, said: "We hope that this study will provide information for future studies to evaluate anxiety treatments that take the host genome and microbiome into account.
"

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