Study on the relationship between Helicobacteria and heterointestinal ulcers

NetworkThe study of the relationship between Helicobacterrobacteria and heterointestinal ulcersHetero-intestinal ulcers is an extremely common disease, which has long been clinically proven, but its etiology and pathogenesis have not yet been fully clarified. For a long time, stomach acid is a necessary condition for the ulcer to occur, has been accepted by us, "no acid, no ulcer" theory, in the pathogenesis of ulcers has been dominant. Since Helicobacter Pylori (Hp) was isolated from the mucous membranes of a person's stomach, the dominant position of stomach acid in the pathogenesis of hexa-fingered ulcer disease has been challenged. Digestive disease experts have put forward the argument that there is no ulcer without HP. We would like to briefly discuss our views on the clinical data of this group and in the literature."No Hp, No Ulcers" advocates are based on the fact that hp infection in the duoon ulcer disease detection rate of up to 95% to 100%, and the eradication of HP, can prevent ulcer recurrence. Hp occupies a certain position in the pathogenesis of terse ulcers, which is generally accepted at present, but what extent does its importance reach? It needs to be studied and explored.1 Clinical dataFrom 1991 to 1995, 88 cases of intestinal ulcer disease, 82 cases of Hp infection (92.1%) and no hp infection were among the hospitalized patients in our department. 6 cases (7.9%), which is similar to the hp infection rate of 12-finger intestinal ulcer disease reported at home and abroad 86.5% to 100%, so high Hp detection rate indicates that Hp is indeed 10 The occurrence of second-finger intestinal ulcers has a certain relationship, however, from 1991-7 to 1994-12 bottom, due to upper abdominal symptoms in our hospital gastroscopy, a total of 4,589 people, Of these, 1,932 (42.1%) were infected with HP, and only 348 (17.4%) of the hp infections were 12-fingered intestinal ulcers, similar to those reported by Jabo. This shows that the majority of Hp infections do not occur in the heteroscope ulcer, the specificity of the two interrelated is not close, that is, the presence of Hp, is not a necessary condition for the occurrence of heterointestinal ulcers. According to a report abroad, 345 cases of indigestion with HP settled without heteoscopic ulcer disease occurred in only 2 cases of 12-finger intestinal ulcers in 3 years of endoscopy and clinical follow-up. Of the 86 hp settlers we followed for two years, only one had a terse ulcer. This also indicates that the incidence of terse ulcers in HP settlers is lower than expected in the general population.2 DiscussionFrom most reports of treatment, whether it is H
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blocker or proton pump blocker, the 4-week healing rate of healing rate of healing of healing intestinal ulcers in the tidal intestinal intestinal omeres is due to. 70.8%～100%。 However, reports of hp clearance rates were highly inconsistent, with Renitedin and Loessek having a 3% to 88.23% hd clearance rate, and some even reported that Losek had no effect on Hp at all, even if it did, but there were significant differences compared to the four-week healing rate for ulcers, not to mention the disease groups that were ineffective for Hp. This suggests that Hp is not a major risk factor in the occurrence of ulcers, and stomach acid plays a more important role. At present, there is no direct evidence of HP into twelve-finger intestinal ulcer disease, it is debatable to confirm prematurely that Hp is the source of the disease, and even to conclude that the disease is an infectious disease. Recurrence of duoon ulcers is an important problem in treatment, although recurrence involves a variety of factors, but hp has not been eradicated, in the recurrence of ulcers, there is a very important role. After any individual acid suppression treatment, the recurrence rate of ulcers 1a up to 85% of the eradication of HP antibacterial drugs or antimony agents, ulcer healing rate is not as good as acid inhibitors, but the recurrence rate of ulcers is greatly reduced.In summary, we believe that Hp is a risk factor in the occurrence of duobial ulcers, but not the source of duobial ulcers, in the occurrence of ulcers, the role of stomach acid is more important than Hp, but in the recurrence of ulcers, Hp does play an important role.Xinlan Xu HongzheSecond Affiliated Hospital of Xinjiang Medical College (Urumchi 830028)