[Study] Rescue "night owls"-changes in diet found in the microbiome differences between early risers and late sleepers

This article is original by Translational Medicine.
Please indicate the source for reprinting.
Author: Ashley Guide: Are you a night owl? Due to various reasons, there are more and more night owls, don't follow suit! Night owls have a significant impact on the risk of mood disorders, obesity, diabetes and other chronic diseases
.

Recent studies have examined the differences in the composition of the gut microbiome of the early risers and late sleepers, and found that there is a connection between people's gut microbiome, eating behaviors, and sleep patterns
.

These findings are likely to pave the way for changing these patterns through dietary changes
.

A joint research project between the University of Haifa and the Technion-Israel Institute of Technology found that the gut microbiomes (groups of bacteria that reside in the digestive tract) of "early people" and "night owls" are different from each other
.

This research was carried out in collaboration with a number of research groups from the University of Haifa and the Technion-Israel Institute of Technology
.

Professor Eran Tauber, Director of the Biological Clock Laboratory of the Department of Evolution and Environmental Biology, Haifa University, and his laboratory manager Dr.
Bettina Fishman, Professor Tamar Shochat, and Liel Stelmach Lask, a research student in the Cheryl Spencer Department of Nursing, Haifa University, and the Microbiome Research of the Technion Rappaport School of Medicine The head of the laboratory, Dr.
Naama Geva-Zatorsky, and her doctoral student Shaqed Carasso
.

The challenge of this study is to detect differences in the composition of the gut microbiome in the early risers and late sleepers
.

Professor Tauber said: "This is the first time that people's gut microbiome, eating behavior and sleep patterns have been linked
.

These findings are likely to pave the way for changing these patterns through dietary changes
.

"According to Professor Shochat, "The current practice is to divide people into three different'temporal patterns' (temporal patterns are the body’s natural tendency to wake up or sleep at certain times).
According to early research, it is known that they They are genetically different: "Skylarks"-morning-type people who get up early have the best energy in the morning; "owls"-night owls who sleep late and have difficulty operating in the morning; the middle group makes up most of the population
.

Research conducted in recent years has found that there are significant differences between different time types (physiology, cognition, and their personality structure)
.

It is worth noting that some research on the genetic mechanism that affects the circadian rhythm (our'biological clock') is at the core of the 2017 Nobel Prize in Medicine
.

"Preliminary evidence collected as part of the research on fruit flies in Professor Tauber’s laboratory supports the idea that changes in the composition of the gut microbiome may affect chronological identity
.

Since genes related to circadian rhythms are the same in humans and fruit flies, Therefore, a joint study between the Tauber, Shochat, and Geva-Zatorsky groups suggested to detect whether there are similar relationships in humans.
The study was finally published in the FASEB journal, entitled "Metagenomic analysis reveals the signature of gut microbiota associated with human chronotypes"
The
researchers promoted to the general public and recruited volunteers from all over the country.
They sent stool samples to report their sleep patterns and eating behaviors
.
The
researchers used DNA sequencing of the samples to identify the three time types (morning wake -ups).
The composition of the intestinal flora of 91 volunteers (human, night owl, and intermediate) was characterized
.

The results of the study pointed out the difference between the microbiomes of "Skylark" and "Owl"; in "Skylark", the researchers found that the percentage of bacteria belonging to the genus Alitipes was higher, while in "Owl", the bacteria belonging to the genus Lachnospira was higher.

.

The bacterium is a butyrate-producing bacterium, a short-chain fatty acid, and a source of signals related to sleep and wakefulness
.

When the researchers reviewed the subjects’ daily diet through a questionnaire, they again found a significant difference between morning skylarks and night owls: morning people eat much more fruits and vegetables, mainly drinking water , Do not eat complex carbohydrates; while night owls eat a high-fat diet, a lot of meat, less fruit, and drink drinks containing a lot of sugar
.

Naama Geva-Zatorsky and Shaqed Carasso said: "Research in our laboratory and other laboratories active in this field shows that the composition of our gut microbiome is closely linked to our health
.

Moreover, our eating behavior, diet And habits affect the composition of our gut microbiome
.

The focus of this study is on healthy people, which not only describes how bacteria change between different types of work and rest, but also helps to understand how gut bacteria are affected by our habits, and How they affect us
.

It’s worth noting that causality has not been proven, and this will be the focus of our next research
.

"Indeed, according to the researchers, it is determined whether the difference in microbiome composition affects the attribution of different time types.
It is still too early to be affected by it, or whether the causality at work here is more complicated
.

In other words, the fact that this connection was discovered for the first time opened up opportunities for research on this topic
.

"Owl" is characterized by a large number of bacteria that produce butyrate, which is an amino acid linked to the sleep/wake rhythm, which supports the hypothesis that there is a connection between sleep/wake patterns and the composition of the intestinal flora
.

At the same time, the preliminary evidence on fruit fly research collected in Professor Tauber's laboratory reinforces the view that changes in the composition of the microbiome may affect temporal identity
.

Professor Tauber said: "Nowadays, the daily habits of Western society often make the life of night owls difficult
.

They go to bed late and have to get up early to start daily work, so they often lack sleep
.

We also know that many night owls suffer from depression, diabetes and Obesity and other problems
.

We hope that if we can change the bacterial population that lives in our digestive tract, for example, by changing our diet and eating habits, we may be able to affect the sleep patterns of "owls" and improve their quality of life
.

"Reference material: https://phys.
org/news/2022-01-microbiome-differences-night-owls-morning.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.

If you need health guidance, please go to a regular hospital for treatment
.

Popular·Article Basic Research [Science Sub-Journal] Transforming artificial lungs-lizards provide amazing methods! Intestinal flora [Nature] Did you take hypoglycemic drugs ineffective? Because the intestinal microflora is in the process of cancer treatment [PNAS] Chinese medicinal materials thyme and oregano have found anti-cancer compounds for disease diagnosis and treatment [Nature Sub-Journal] This is another step towards changing the US$70 billion global diagnostic industry! Protein biosensors can measure toxic drugs for cardiovascular disease in cancer, arthritis, and organ transplant patients [JAMA Sub-Journal] Are you stressed? Stress increases the risk of cardiovascular disease! Scientific research [Cell Sub-Journal] Why do pain and anxiety speed up the breathing rate? The scientific research "Science" announced the breakthrough of 2021: a problem that has troubled biologists for 50 years was solved by AI and realized the dream of a Nobel Prize winner!