Study reveals the metabolic regulation mechanism of fatty liver developing into liver cancer

Recently, the research group of Yang Wulin, a researcher from the Institute of Health , Hefei Institute of Material Science , Chinese Academy of Sciences , has made new progress in the field of tumorigenesis and discovered a metabolic regulation mechanism that promotes the malignant transformation of non-alcoholic steatohepatitis
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Fatty liver is a common liver pathological change with excessive accumulation of fat in liver cells.
It is the second major liver disease after viral hepatitis
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Starting from the STAM mouse model that mimics the evolution of human fatty liver disease, the research team analyzed the gene expression patterns and gene set variation at each stage of the disease, and found that the extensive activation of carcinogenic signals occurred at the stage of non-alcoholic steatohepatitis, accompanied by regulatory fatty acids.
Specific up-regulation of the metabolic signal axis
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This result suggests that the activation of the fatty acid metabolism signal axis is an important factor in the formation and maintenance of liver cancer initiating cells, and targeting this signal axis may provide a potential direction for the prevention of non-alcoholic steatohepatitis-related hepatocellular carcinoma
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Related paper information: https://doi.