-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
▎The editor of WuXi AppTec's content team is inextricably linked to smoking and lung cancer.
Every year, more than 2 million people worldwide are diagnosed with lung cancer, and most of them have a history of smoking
.
It is worth noting that nearly 10% to 20% of lung cancer patients have never smoked.
This part of the lung cancer patients who have never smoked are more common in women, and they occur at an earlier age
.
Where did their cancer cells come from? Recently, a blockbuster study published in Nature Genetics in the form of a cover paper conducted a genome-wide analysis of lung cancer patients without smoking history.
It is caused by the accumulation of gene mutations in the natural physiological process of the human body
.
According to the paper, the current study "revealed for the first time that there are three different molecular subtypes of lung cancer in lung cancer patients without a history of smoking.
" Based on the progress characteristics of these three subtypes, more precise treatment may help to improve The prognosis of this part of the patient
.
Screenshot source: Nature Genetics Previous studies have shown that environmental risk factors (such as exposure to second-hand smoke, radon, air pollution or asbestos) or a history of lung disease may cause some people who have never smoked to develop lung cancer.
In addition, there are still The cause of lung cancer in most never-smokers is unknown
.
The current study is led by researchers from the National Cancer Institute (NCI) under the National Institutes of Health (NIH).
The researchers used whole-genome sequencing methods to examine 232 cases of no smoking history (27.
6% exposure to second-hand smoke) and Analysis of genomic changes in tumor tissues and matched normal tissues in untreated non-small cell lung cancer (NSCLC) patients
.
Among the patients included in the study, 189 cases were lung adenocarcinoma (the most common subtype of lung cancer), 36 cases were lung carcinoid, and the remaining 7 cases were other subtypes of NSCLC; 97.
4% of the patients were of European descent
.
After combing the characteristics of mutations in the patient's tumor genome, the researchers judged the source of the cancer-causing mutations and determined whether these mutations came from the body's natural processes (such as DNA repair errors or oxidative stress) or from exposure to carcinogens
.
The results show that the tumor genomes of most lung cancer patients without smoking history have mutations related to the damage of endogenous processes (that is, natural processes that occur in the body).
That is to say, the tumors are naturally occurring gene mutations in the body.
Caused by accumulation
.
Because the study only included lung cancer patients without a history of smoking, the researchers did not find any mutations associated with direct tobacco exposure
.
The researchers also did not find these mutations in 62 patients exposed to second-hand smoke, but this may be related to the small sample size of the current study and the large differences in the exposure levels of patients
.
In addition, genome analysis also revealed three new molecular subtypes in lung cancer patients without a history of smoking.
Researchers named these three subtypes "piano" and "piano" based on different levels of somatic copy number variation (SCNA).
"Mezzo-forte" and "forte" subtypes: ▪ piano type (weak SCNA level): the mutation level is the lowest, but it is dominant in the study of lung cancer patients without a history of smoking (it is more in lung cancer patients with a history of smoking) Rare); this subtype of tumor grows extremely slowly, because there may be a variety of different oncogenic driver mutations (such as KRAS mutation, somatic UBA1 mutation, germ cell AR mutation), so it is difficult to treat; in addition, this subtype of tumor The production seems to be related to the activation of progenitor cells
.
▪ Mezzo-forte type (medium level of SCNA): This subtype of tumor has specific chromosomal changes and EGFR gene mutations
.
▪ Forte type (strong SCNA level): This subtype of tumor grows fast and exhibits the characteristics of genome-wide doubling (WGB)
.
▲ Genomic mutation characteristics of the three subtypes of lung cancer (picture source: reference [1]) Professor Maria Teresa Landi, the corresponding author of this study, said, "Based on the characteristics of these three different subtypes of lung cancer, we are expected to adopt different prevention or treatment methods.
Carry out more precise intervention
.
For example, for slow-growing piano-type lung cancer, we can detect it in time and cure it through surgery as soon as it progresses to be more difficult to treat; while mezzo-forte and forte subtypes of lung cancer are only a few These major oncogenic driver mutations may be identified by a single biopsy, and these patients are expected to benefit from targeted therapy
.
"Related reading prevention! Air pollution is the second leading cause of lung cancer, and the incidence in China is worth paying attention to.
JAMA: Air pollution accelerates the risk of severe lung disease, which is equivalent to smoking 3 packs of cigarettes a day! Over 60% of lung cancer deaths are this common cause! The Knife magazine published a report on the global burden of respiratory cancer.
The Lancet magazine: One screening reduces the risk of death from lung cancer by about 1/3! LDCT gains additional evidence from the international Yale Cancer Center team: These strategies are promising in the next ten years Cure non-small cell lung cancer question map source: 123RF reference materials [1] TongwuZhang, et al.
, (2021).
A compendium of uniformly processed human gene expression and splicing quantitative trait loci.
Nature Genetics, DOI:10.
1038/s41588-021-00920 -0[2] Study illuminates origins of lung cancer in never smokers.
Retrieved September 24,2021, fromhttps://medicalxpress.
com/news/2021-09-illuminates-lung-cancer-smokers.
htmlDisclaimer: WuXi AppTec The content team focuses on introducing the progress of global biomedical health research
.
This article is for information exchange purposes only.
The opinions in the article do not represent WuXi AppTec's position, nor does it mean that WuXi AppTec supports or opposes the views
in the
article .
This article is not a treatment plan recommendation
.
If you need to get it For treatment plan guidance, please go to a regular hospital for treatment
.
Every year, more than 2 million people worldwide are diagnosed with lung cancer, and most of them have a history of smoking
.
It is worth noting that nearly 10% to 20% of lung cancer patients have never smoked.
This part of the lung cancer patients who have never smoked are more common in women, and they occur at an earlier age
.
Where did their cancer cells come from? Recently, a blockbuster study published in Nature Genetics in the form of a cover paper conducted a genome-wide analysis of lung cancer patients without smoking history.
It is caused by the accumulation of gene mutations in the natural physiological process of the human body
.
According to the paper, the current study "revealed for the first time that there are three different molecular subtypes of lung cancer in lung cancer patients without a history of smoking.
" Based on the progress characteristics of these three subtypes, more precise treatment may help to improve The prognosis of this part of the patient
.
Screenshot source: Nature Genetics Previous studies have shown that environmental risk factors (such as exposure to second-hand smoke, radon, air pollution or asbestos) or a history of lung disease may cause some people who have never smoked to develop lung cancer.
In addition, there are still The cause of lung cancer in most never-smokers is unknown
.
The current study is led by researchers from the National Cancer Institute (NCI) under the National Institutes of Health (NIH).
The researchers used whole-genome sequencing methods to examine 232 cases of no smoking history (27.
6% exposure to second-hand smoke) and Analysis of genomic changes in tumor tissues and matched normal tissues in untreated non-small cell lung cancer (NSCLC) patients
.
Among the patients included in the study, 189 cases were lung adenocarcinoma (the most common subtype of lung cancer), 36 cases were lung carcinoid, and the remaining 7 cases were other subtypes of NSCLC; 97.
4% of the patients were of European descent
.
After combing the characteristics of mutations in the patient's tumor genome, the researchers judged the source of the cancer-causing mutations and determined whether these mutations came from the body's natural processes (such as DNA repair errors or oxidative stress) or from exposure to carcinogens
.
The results show that the tumor genomes of most lung cancer patients without smoking history have mutations related to the damage of endogenous processes (that is, natural processes that occur in the body).
That is to say, the tumors are naturally occurring gene mutations in the body.
Caused by accumulation
.
Because the study only included lung cancer patients without a history of smoking, the researchers did not find any mutations associated with direct tobacco exposure
.
The researchers also did not find these mutations in 62 patients exposed to second-hand smoke, but this may be related to the small sample size of the current study and the large differences in the exposure levels of patients
.
In addition, genome analysis also revealed three new molecular subtypes in lung cancer patients without a history of smoking.
Researchers named these three subtypes "piano" and "piano" based on different levels of somatic copy number variation (SCNA).
"Mezzo-forte" and "forte" subtypes: ▪ piano type (weak SCNA level): the mutation level is the lowest, but it is dominant in the study of lung cancer patients without a history of smoking (it is more in lung cancer patients with a history of smoking) Rare); this subtype of tumor grows extremely slowly, because there may be a variety of different oncogenic driver mutations (such as KRAS mutation, somatic UBA1 mutation, germ cell AR mutation), so it is difficult to treat; in addition, this subtype of tumor The production seems to be related to the activation of progenitor cells
.
▪ Mezzo-forte type (medium level of SCNA): This subtype of tumor has specific chromosomal changes and EGFR gene mutations
.
▪ Forte type (strong SCNA level): This subtype of tumor grows fast and exhibits the characteristics of genome-wide doubling (WGB)
.
▲ Genomic mutation characteristics of the three subtypes of lung cancer (picture source: reference [1]) Professor Maria Teresa Landi, the corresponding author of this study, said, "Based on the characteristics of these three different subtypes of lung cancer, we are expected to adopt different prevention or treatment methods.
Carry out more precise intervention
.
For example, for slow-growing piano-type lung cancer, we can detect it in time and cure it through surgery as soon as it progresses to be more difficult to treat; while mezzo-forte and forte subtypes of lung cancer are only a few These major oncogenic driver mutations may be identified by a single biopsy, and these patients are expected to benefit from targeted therapy
.
"Related reading prevention! Air pollution is the second leading cause of lung cancer, and the incidence in China is worth paying attention to.
JAMA: Air pollution accelerates the risk of severe lung disease, which is equivalent to smoking 3 packs of cigarettes a day! Over 60% of lung cancer deaths are this common cause! The Knife magazine published a report on the global burden of respiratory cancer.
The Lancet magazine: One screening reduces the risk of death from lung cancer by about 1/3! LDCT gains additional evidence from the international Yale Cancer Center team: These strategies are promising in the next ten years Cure non-small cell lung cancer question map source: 123RF reference materials [1] TongwuZhang, et al.
, (2021).
A compendium of uniformly processed human gene expression and splicing quantitative trait loci.
Nature Genetics, DOI:10.
1038/s41588-021-00920 -0[2] Study illuminates origins of lung cancer in never smokers.
Retrieved September 24,2021, fromhttps://medicalxpress.
com/news/2021-09-illuminates-lung-cancer-smokers.
htmlDisclaimer: WuXi AppTec The content team focuses on introducing the progress of global biomedical health research
.
This article is for information exchange purposes only.
The opinions in the article do not represent WuXi AppTec's position, nor does it mean that WuXi AppTec supports or opposes the views
in the
article .
This article is not a treatment plan recommendation
.
If you need to get it For treatment plan guidance, please go to a regular hospital for treatment
.
