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Common name: Iron sucrose English name: Ferrous Saccharose Alias: Villefort, Venofer Cas No: 8047-67-4 Molecular weight: 736.
06 Molecular formula: C18H24Fe2O24 Nanjing Chenruisheng Biological Pharmacological Effects of Raw Material Sucrose Iron: Ferrosucrose is a polynuclear iron hydroxide (III.
), and the core surface is surrounded by a large number of non-covalently bound sucrose molecules, forming a complex with an average molecular weight of 43kDa
。
This macromolecular structure can be avoided from being eliminated from the kidneys
.
This complex is structurally stable and releases iron ions
under reasonable conditions.
Nanjing Chenruisheng Biological to carry out raw material preparation: Route 1: The trivalent iron salt and the inorganic alkali are reacted to prepare the iron hydroxide colloid under 5 ~ 20 ° C conditions, the iron hydroxide colloid is then complexed with sucrose at 100 ~ 120 ° C to obtain the sucrose iron solution, the sucrose iron solution is dried by spray to obtain a solid, the specific reaction process is as follows: Route 2:1) Crystallization: the pH of the sucrose solution is adjusted to 1 to 4 with acetic acid, and the iron salt solution is added to the sucrose solution to form a mixture.
Use Na2CO3 solution to adjust the pH value of the mixed to 1 ~ 3, stir, continue to add Na2CO3 solution until the mixture appears turbid and the pH value of the mixture is adjusted to 4 ~ 7, filter, add water to obtain discus solution; 2) Complexation: the sucrose solution is heated, the lye is added for alkalinization, and the discus solution is added to the alkalized sucrose solution, and the complexing solution is obtained overnight.
3) Refining: the complex solution after resting overnight is filtered, and the filtrate is precipitated with 2 to 3 times of 95% ethanol, which is sucrose iron
.
Nanjing Chenruisheng Biological development of raw material iron sucrose topic: the application of iron sucrose in hemodialysis patients is a relatively safe and effective supplemental iron drug, the use of iron sucrose is 100mg / stick, generally need to use 100ml of normal saline plus a piece of iron sucrose dilution after intravenous infusion
.
Nanjing Chenruisheng Biological to carry out the use of raw material iron sucrose and precautions: iron sucrose injection is a sterile, multinucleated iron hydroxide sucrose complex solution injected intravenously, which is the oldest intravenous iron supplement used
.
Iron sucrose is prepared by the complexation of iron hydroxide colloid and sucrose, which is a water-soluble iron hydroxide sucrose complex, which contains iron in a nonionic state with an average molecular weight of 34000-60000Da
.
Side effects of iron sucrose, which has been marketed in Switzerland since 1950: Iron sucrose is an iron supplement that is less effective for oral iron supplementation and generally requires intravenous iron therapy
.
The infusion of iron sucrose has a certain irritation to blood vessels and soft tissues, and local swelling, pain and phlebitis
may occur.
The clinical manifestations of phlebitis are mainly adverse reactions in the blood vessels of intravenous administration, and there is a sense of needle pricking in the local area
of compression.
Intravenous injection of the blood vessels appears stiff, tender and goes along the blood vessels