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| Suffering from the new crown will damage the brain's cognitive function |
Science and Technology Daily, Beijing, October 25 (intern reporter Zhang Jiaxin) A new study conducted by scientists from Germany, France and Spain found that the new coronavirus kills brain cells called endothelial cells, causing damage to cerebral blood vessels, thereby damaging brain blood vessels.
Cognitive function
.
Related papers were published in the recent "Nature Neuroscience" magazine
Previous studies have found that as many as 84% of patients with new coronary pneumonia have neurological symptoms, loss of taste or smell, seizures, stroke, loss of consciousness and confusion, which may be one of the reasons
.
Researchers studied the brains of patients who died of new coronary pneumonia and found that their chord blood vessels increased
.
The chord vessels are dead cells that cannot allow blood to flow
Researchers believe that chord blood vessels are similar or at least partly the same as tunnel nanotubes (a new type of cell-to-cell communication connection), and nanotubes are thought to be involved in regulating the coupling of cerebral blood vessels
.
Regardless of this function, chordal vessels are strongly related to endothelial cell death, blood-brain barrier destruction and cerebral ischemia
How does the new coronavirus cause the death of brain endothelial cells? The results showed that Mpro, the main protease of the new coronavirus, can efficiently cleave NEMO, the basic regulator of host cell nuclear factor-κB
.
In infected cells, both Mpro and NEMO are located in the cytoplasm and nucleus
The study also found that the loss of receptor-interacting protein kinase 3 (RIPK3) is a mediator of regulated cell death, which can prevent the thinning of blood vessels and the destruction of the blood-brain barrier caused by NEMO ablation
.
Importantly, pharmacological inhibitors of RIPK signaling prevent Mpro-induced microangiopathy
Researchers said that this process of new coronary pneumonia may be reversible
.
Vincent Prevo, the co-author of the paper, said: "We have seen that in hamsters with mild new coronary pneumonia, this phenomenon is obviously reversible, so we hope it can be reversed in humans
Focus on the new crown pneumonia epidemic
