Summary of alkaloid separation purification techniques

Alkaloid is a very heavy component of natural Chinese herbs, currently used to separate the function of purified this class of substances
fills
the market has not yet developed an effective separation of purified alkaloids efficient fillers, so the separation of this type of substances are used in the conventional method. The Division of the separation of alkaloids this kind of material using conventional methods, summarized some techniques, to obtain alkaloid yield is high, purity is also better.
To de-acetylene as an example, de-iso-polding belongs to iso-alkaloid, according to the conventional method of separating alkaloids is to extract, concentrate, and then use ethyl acetate or dichloromethane for extraction, and then through silicone column column layer separation, collected to the main product segment of the product, and then secondary silicone column purification or crystallization to obtain pure products;
But the extraction of the original medicinal herbs is black medicine, the extraction concentrate is more viscous, and the color is also very dark, direct extraction, on the one hand, the emulsification is serious, on the other hand, the consumption of
organic
reagents
is also more, greatly increasing the cost.
Through a large number of research and development, the Division summarized some techniques:
Tips one: the use of large-hole resin abundant, while carrying out
acryl
reasonable adjustment, flexible use of alkaloid free state and hydrochloride form
-transformation
, so that the separation process of alkaloids reduce costs, simplify the production steps, synchronization, the rise of alkaloid purity also get a good improvement;
Tip 2: Flexible and rational use of crystallization methods, specifically crystallization and silicone column clever combination, through silicone column to improve the color and viscosity of the product semi-finished products, and then use crystallization techniques to complete the product purity rise, the rational selection of
crystallization reagents and the strict control of crystallization parameters is critical, the Division uses conventional methods, conventional reagents but through the technique of alkaloid separation and purification to achieve the efficient separation and purification of alkaloid components, low cost, high yield, accumulated different types of alkaloid separation purification process.