Sun Yat-sen University discovers new targets for colorectal cancer treatment

The team of Professor Chen Shuai of Sun Yat-sen University Cancer Center has found candidate therapeutic targets for colorectal cancer through shRNA library combined with next-generation sequencing technology.

Colorectal cancer is one of the most common malignant tumors worldwide.

DKC1 belongs to the pseudouracil synthase family, which catalyzes the modification of pseudouracil (ψ) in RNA.

Researchers found that the expression level of DKC1 is abnormally elevated in colorectal cancer tissues, and its high expression is significantly related to the poor prognosis of patients.

Chen Shuai pointed out that the above research shows that DKC1 is a new candidate target for the treatment of colorectal cancer.

In the wave of searching for cancer chemotherapy drugs in the last century, pyrazofurin as a nucleoside synthesis inhibitor has been clinically tested in a variety of tumors including colorectal cancer, but the efficacy is not satisfactory.

The study revealed a new target for the treatment of colorectal cancer, DKC1, and explained the rationality of the combined use of DKC1 inhibitors and RAF/MEK/ERK signaling pathway inhibitors through drug mechanism and animal experimental studies, which is expected to provide new drug development for colorectal cancer New choice.

Related paper information: org/10.