-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
| Circulation Research [IF:2213] ① Integrated analysis of gut microbiota and metabolome showed that indole-3-propionic acid (IPA, a microbiota metabolite of tryptophan) was significantly reduced in patients with coronary heart disease (CAD); ② In another cohort, blood IPA The level is negatively correlated with the risk and severity of atherosclerotic cardiovascular disease; ③ Combined cell experiments and mouse experiments with IPA supplementation/depletion showed that IPA acts on macrophages to induce ABCA1 expression by inhibiting miR-142-5p, This promotes the efflux of cholesterol from macrophages and has a protective effect on atherosclerosis; ④ In patients with CAD, the miR-142-5p/ABCA1/cholesterol reverse axis of macrophages is dysregulated, and is associated with decreased blood I. Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease07-27, doi: 11161/ CIRCRESA. 12321253 In a recent study published by his team in Circulation Research, it was found that the gut microbiota metabolite indole-3-propionic acid (IPA) can promote cholesterol reversion in macrophages through the miR-142-5p/ABCA1 axis in humans and mice Therefore, it has a protective effect on atherosclerotic cardiovascular disease (ASCVD) and provides a new potential intervention target for improving ASC. (@mildbreeze) Disclaimer: This article only represents the author's personal opinion and has nothing to do with China Probiotics Netwo. Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and te. Readers are only for reference and please Verify the relevant content yourse. Copyright Notice Some articles reproduced on this site are not original, and their copyright and responsibility belong to the original auth. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and the source and author are clearly indicat. Media or individuals who do not wish to be reprinted can contact us for infringing information that can provide sufficient eviden. , bio149 will be deleted within 12 hours after confirmati. Users are welcome to submit original articles to 86371366@. com, which will be published on the homepage after review, and the copyright and responsibility of the articles belong to the send. |
[IF:2213]
① Integrated analysis of gut microbiota and metabolome showed that indole-3-propionic acid (IPA, a microbiota metabolite of tryptophan) was significantly reduced in patients with coronary heart disease (CAD); ② In another cohort, blood IPA The level is negatively correlated with the risk and severity of atherosclerotic cardiovascular disease; ③ Combined cell experiments and mouse experiments with IPA supplementation/depletion showed that IPA acts on macrophages to induce ABCA1 expression by inhibiting miR-142-5p, This promotes the efflux of cholesterol from macrophages and has a protective effect on atherosclerosis; ④ In patients with CAD, the miR-142-5p/ABCA1/cholesterol reverse axis of macrophages is dysregulated, and is associated with decreased blood I.
Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease07-27, doi: 11161/ CIRCRESA.
12321253 In a recent study published by his team in Circulation Research, it was found that the gut microbiota metabolite indole-3-propionic acid (IPA) can promote cholesterol reversion in macrophages through the miR-142-5p/ABCA1 axis in humans and mice Therefore, it has a protective effect on atherosclerotic cardiovascular disease (ASCVD) and provides a new potential intervention target for improving ASC.
(@mildbreeze)
Disclaimer: This article only represents the author's personal opinion and has nothing to do with China Probiotics Netwo.
Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and te.
Readers are only for reference and please Verify the relevant content yourse.
Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and te.
Readers are only for reference and please Verify the relevant content yourse.
Copyright Notice
Some articles reproduced on this site are not original, and their copyright and responsibility belong to the original auth.
All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and the source and author are clearly indicat.
Media or individuals who do not wish to be reprinted can contact us for infringing information that can provide sufficient eviden.
, bio149 will be deleted within 12 hours after confirmati.
Users are welcome to submit original articles to 86371366@.
com, which will be published on the homepage after review, and the copyright and responsibility of the articles belong to the send.
Circulation ResearchAll reprinted articles, links and pictures on this website are for the purpose of conveying more information, and the source and author are clearly indicat.
Media or individuals who do not wish to be reprinted can contact us for infringing information that can provide sufficient eviden.
, bio149 will be deleted within 12 hours after confirmati.
Users are welcome to submit original articles to 86371366@.
com, which will be published on the homepage after review, and the copyright and responsibility of the articles belong to the send.
[IF:2213]
① Integrated analysis of gut microbiota and metabolome showed that indole-3-propionic acid (IPA, a microbiota metabolite of tryptophan) was significantly reduced in patients with coronary heart disease (CAD); ② In another cohort, blood IPA The level is negatively correlated with the risk and severity of atherosclerotic cardiovascular disease; ③ Combined cell experiments and mouse experiments with IPA supplementation/depletion showed that IPA acts on macrophages to induce ABCA1 expression by inhibiting miR-142-5p, This promotes the efflux of cholesterol from macrophages and has a protective effect on atherosclerosis; ④ In patients with CAD, the miR-142-5p/ABCA1/cholesterol reverse axis of macrophages is dysregulated, and is associated with decreased blood I.
Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease07-27, doi: 11161/ CIRCRESA.
12321253 In a recent study published by his team in Circulation Research, it was found that the gut microbiota metabolite indole-3-propionic acid (IPA) can promote cholesterol reversion in macrophages through the miR-142-5p/ABCA1 axis in humans and mice Therefore, it has a protective effect on atherosclerotic cardiovascular disease (ASCVD) and provides a new potential intervention target for improving ASC.
(@mildbreeze)
Disclaimer: This article only represents the author's personal opinion and has nothing to do with China Probiotics Netwo.
Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and te.
Readers are only for reference and please Verify the relevant content yourse.
Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and te.
Readers are only for reference and please Verify the relevant content yourse.
Copyright Notice
Some articles reproduced on this site are not original, and their copyright and responsibility belong to the original auth.
All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and the source and author are clearly indicat.
Media or individuals who do not wish to be reprinted can contact us for infringing information that can provide sufficient eviden.
, bio149 will be deleted within 12 hours after confirmati.
Users are welcome to submit original articles to 86371366@.
com, which will be published on the homepage after review, and the copyright and responsibility of the articles belong to the send.
Circulation Research Circulation ResearchAll reprinted articles, links and pictures on this website are for the purpose of conveying more information, and the source and author are clearly indicat.
Media or individuals who do not wish to be reprinted can contact us for infringing information that can provide sufficient eviden.
, bio149 will be deleted within 12 hours after confirmati.
Users are welcome to submit original articles to 86371366@.
com, which will be published on the homepage after review, and the copyright and responsibility of the articles belong to the send.
[IF:2213]
[IF:2213]① Integrative analysis of gut microbiota and metabolome showed that indole-3-propionic acid (IPA, a microbiota metabolite of tryptophan) was significantly reduced in patients with coronary heart disease (CAD); ② In another In the cohort, blood IPA levels were negatively correlated with the risk and severity of atherosclerotic cardiovascular disease; ③ Combined cell experiments and mouse experiments with IPA supplementation/depletion showed that IPA acts on macrophages by inhibiting miR-142-5p to induce the expression of ABCA1, thereby promoting the efflux of cholesterol from macrophages, and has a protective effect on atherosclerosis; ④ In patients with CAD, the miR-142-5p/ABCA1/cholesterol reverse axis of macrophages is dysregulated, and is associated with blood I.reduce correlati.
Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease07-27, doi: 11161/ CIRCRESA.
12321253 In a recent study published by his team in Circulation Research, it was found that the gut microbiota metabolite indole-3-propionic acid (IPA) can promote cholesterol reversion in macrophages through the miR-142-5p/ABCA1 axis in humans and mice Therefore, it has a protective effect on atherosclerotic cardiovascular disease (ASCVD) and provides a new potential intervention target for improving ASC.
(@mildbreeze)
