Sun's team revealed a new mechanism for inhibition of the neutral granulocyte's ability to become more functional

April 10, the internationally renowned academic journal Proceedings of the National Academy of Sciences published online the results of the research of Professor Sun Wei's team at Jiangsu University Hospital, "Endotoxin induced autocrine ATPing at signaling inhibitors neutrophils chemotaxis through enhancing myosin light chainphosphorylation" (endotoxin-induced autocytoxin light-chain phosphorylation inhibits neutral granulation. The study was funded by the National Natural Science Foundation of China.
The body's natural immune cells - neogenic granulocytes are the blood's most abundant immune cells, bacteria infection in the early stages, neutral granulocytes can detect the signal of bacteria, in the precise "navigation" of the chemical molecules quickly from the blood vessels to the pathogen site, play a powerful role in devouring and killing bacteria. Bacterial endotoxin is the main component of the surface of Glollane-negative bacteria cell wall, when serious infection bacteria release a large number of endotoxins, endotoxins with blood circulation to the whole body of tissues and organs, causing systemic poisoning symptoms; This is one of the most important causes of death in severely infected patients.
Professor Sun's team spent more than three years discovering the mechanism by which bacterial endotoxins can "navigate" neutral granulocytes: normal phosphate and polarization of neutral granulocyte skeleton protein MLC control the extension and contraction of neutral granulocyte tails, playing an important role in ensuring the direction of neutral granulocytes. After stimulating neutral granulocytes, it stimulates the self-secretion of ATP by neutral granulocytes, and the ATP/P2X1/Ca2 plus signaling path, which leads to abnormal phosphate and polarization of cytosteorlin MLC, disrupts the direction of neutral granulocytes, and ultimately affects their bactericidal function when they reach the inflammatory site." serious infection and sepsis are one of the main causes of death in hospital patients, ensuring that the neutral granulocyte 'navigation' system is normal for the treatment of serious infection is of great significance. Dr. Wang Xu, the first author of the paper, said, "It is very important to make clear that the abnormal activity of the attestion at ATP/P2X1/Ca2 plus signaling path is likely to be a key molecular mechanism for damage to the neutral granulocyte "navigation" system in the event of a serious infection, and we will use this as an intervention target to conduct in-depth research to provide an important theoretical basis for the precise treatment of serious infections and to give full play to its potential conversion application value." (Source: Science.com)