Super clean pelletizing production line

In order to make the multi-functional equipment run, we must focus on the automatic cleaning In this regard, the example introduced in this paper can give you some inspiration - using the newly designed metal filter device can significantly shorten the sanitary cleaning time of pharmaceutical production equipment "Due to the frequent conversion of different drug varieties, the production equipment for multi product production has a long downtime Therefore, we attach great importance to the optimization of the sanitary cleaning time of pharmaceutical production equipment " Daniel leuthardt, head of production and quality at mepha's non pharmaceutical plant in Switzerland, introduced the new granulation line The granulation production line developed and manufactured by OYSTAR h ü ttlin company consists of htg800 type high shear mixer and hfgc200 type fluidized bed The pneumatic control system is used for loading and unloading of the production line, and the pneumatic system is also used for transportation and transmission among all stations, so that the height of the whole production line is low, and the installation of all production lines can be completed in the height space of one floor As a real multi-functional production line, the working pressure of all compressed air systems of the whole equipment is 10 bar Therefore, it is also suitable for the production of products with Zui small energy less than 3mj In order to complete as many different production processes as possible, this equipment has the ability to granulate and dry directly in the fluidized bed For this reason, a set of bottom jet system is integrated in the fluidized bed, so that the particles in the fluidized bed can be made into particles more directly As the fluidized bed also undertakes the task of coating the tablets and micro tablets with sugar, the equipment plays a role of "generalist" between the pre and post process of tablet production Mischoorgan gentlewing, a compact wet granulation unit, has developed and produced a very compact and solid granulation equipment with excellent raw material transportation performance The main transport push plate moving along the wall of the cylindrical container can not only transport the mixed effective pharmaceutical ingredients and auxiliary ingredients, but also transport the manufactured pharmaceutical particles up to the middle part, so as to ensure that there is no dead angle when the mixer is working, and the mixing time and working cycle time of raw materials are relatively short The amount of mixed raw materials hanging on the wall of the container is very small, and the discharging push plate raised from the height to the mixer cover can also avoid the phenomenon of hanging on the wall, thus ensuring the automation of the production process without manual intervention In the mixer, the real granulation is between the main push plate and the vessel wall Through the specially designed mixing plate structure, some small particles are transported and compacted through the space between the main push plate and the container wall Part of the input energy is directly used for granulation, rather than rotation Therefore, it can also complete the granulation of drugs that are very sensitive to temperature changes The special emptying valve can send the intermediate products into the pneumatic conveying pipeline through the wet abrasive machine, thus realizing the emptying of the production equipment The mixing mechanism relies on the trafficability of the container wall and the special bottom mechanism to ensure the complete emptying of the residue Fig 2 the cleaning nozzle in the center of the equipment can rotate the key core parts of the two equipment in the nonpharmaceutical plant of mepha with uniform particle size within 360 ° and the key core parts of hdgc200 type fluidized bed are specially designed and protected bottom jet device - diskjet gas splitter It allows the solid components of the drug to be ejected with the gas Because the gas divider plate has the ability to make the air flow through form a rotating air flow, so as to ensure a good mixing effect and uniform injection effect According to the different humidity of the gas, the solid pharmaceutical ingredients can be dried, heated, humidified, cooled or agglomerated by adding the binder and coated materials for sugar coating These directional flow of air have a short homogenization time before spraying, thus ensuring that each particle has a uniform drying time Combined with the nozzle installed at the bottom, the jet air flow has Zui excellent flow state The flat bottom plane and the long and narrow slit inclined to the working chamber avoid the gas separation plate of the raw materials of the medical products, and it is also very easy to clean If the drug particles accumulate, or the drug particles are sandwiched in the slit in the process of sanitary cleaning, the inclined structure of the slit can also effectively prevent the drug particles from being stuck in the slit The structure design in accordance with GMP production management technical specifications and the components optimized for sanitation make the sanitation work of pelletizing production line more favorable and shorten the time required for sanitation To avoid cross contamination, non pharmaceutical factories like mepha company use different production processes to produce different varieties of non pharmaceutical products Therefore, the sanitation of pharmaceutical production equipment needs to reach a very high level to avoid cross contamination The key point of the new super clean cleaning solution is that the automatic cleaning time of the complete equipment is shortened The complete CIP in-situ cleaning often meets the obstacle of metal filter screen, which gathers a lot of residual drugs on the ultra clean room side of the filter At the same time, the metal filter screen also increases the difficulty of cleaning liquid emptying This leads to the use of quite cumbersome cleaning technology, production equipment for a long time to stop production cleaning OYSTAR company has developed and produced a new type of metal filter screen, which can be opened in the process of sanitary cleaning of pharmaceutical production equipment, so as to solve the above problems well The inner part of the filter element is of internal cone type, which can be pulled down by a pull rod to open the filter, so that the solid raw materials on one side of the super clean room can be discharged quickly and conveniently This technical improvement obviously shortens the sanitary cleaning time of the production equipment and ensures the high quality sanitary cleaning effect There is a retractable cleaning nozzle in the center of the fluidized bed coating equipment, which makes the super clean system more efficient The retractable cleaning nozzle can rotate 360 ° at three different extended positions, ensuring the production equipment to be clean more thoroughly The opening size of the nozzle supported by the computer and the rotation speed of the nozzle are combined to realize the design of Zui which meets the needs of equipment cleaning The highshear mixer is also equipped with this cleaning nozzle, which plays a decisive role in the cleaning of control valve, pipeline, mixing device and emptying device In the process of cleaning, each working position of the nozzle plays a decisive role in the cleaning effect, at the same time, it also reduces the manual intervention to the low level of Zui The sanitary cleaning plan with the same performance as the actual needs ensures that the whole set of equipment can be cleaned in a short time in Zui The effectiveness of this system has been confirmed by the fact of successful sanitation The short production time and sanitary cleaning time of customized equipment, high availability of equipment, fast loading and emptying, modern safety protection technology, environmental protection, simple operation and high automation of Zui are the important reasons for mepha to choose this OYSTAR granulation production line This production line is designed and manufactured in full accordance with the requirements and wishes of optimization, and it only takes 8 months to put into operation, because the system has completed the performance test in the company's own technology center In this pelletizing production line, they only slightly adjusted the standard sanitary cleaning plan, as a variant configuration, to ensure the reliability of user investment, and to ensure that the equipment can be put into production at a fast speed of Zui.