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Naloxone, a life-saving drug used to treat opioid poisoning, can reduce brain inflammation in male rats after a stroke. The preclinical study, published in eNeuro, laid the groundwork for the development of the first drug to promote stroke recovery, the number one cause of disability in adults.
has been used to prevent opioid poisoning deaths for a decade and has become a common drug in recent years to deal with the opioid crisis. Although the potential for treatment of naloxone in stroke has been studied, research in this area has been limited to several 1980s studies and uncertain clinical trials.
Brandon Harvey and Micko Airavaara explored the study with their colleagues, who found that starting naloxone therapy for one week a day after a stroke in rats could ease the brain's immune response in the first week and improve nerve function in the second week. A naloxone with weak opioid-like drug-like effects has a similar effect to naloxone for clinical use, so the side effects of the drug's active opioid-like system can be overcome. The researchers gave Narcan, a naloxone nasal spray, to rats through the nasal cavity, and the same dose was safe in humans.
overall, these findings will prompt naloxone to be studied in different animals and observed for longer periods of time to determine recovery, which will eventually be explored in humans to help stroke recovery. (Bio Valley)
![9-[1,1'-biphenyl]-4-yl-3,3'-Bi-9H-carbazole](https://file.echemi.com/fileManage/upload/category/ac71ac0d-8ef6-11ec-89e5-fa163ed06441.png)
