Surprising: Mitochondria in diabetic patients cannot track time

The muscle cells of patients with type 2 diabetes have a destroyed biological clock

Almost all cells regulate their biological processes within 24 hours, which is also called the circadian rhythm of cells

Scientists already know that when our biological clock breaks down due to shift work or sleep disorders, our metabolic health may be affected

Now, an international team of scientists has shown that the skeletal muscles of patients with type 2 diabetes have different circadian rhythms

May help fine-tune treatment time

Professor Juleen R.

They conducted further experiments using clinical trial data from type 2 diabetes patients and mice, and cell-based experiments

Some of the most widely used type 2 diabetes medications affect mitochondria, which means that the role of mitochondria may vary depending on the time of administration

Exercise and diet can affect time

 "Exercise and diet are common therapeutic interventions used by patients with type 2 diabetes.

Original search:

" Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle .