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Sustainable source of immunodeficiency virus-fighting immune cells

 Last Update: 2022-04-19
 Source: Internet
 Author: User

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Image: monkey induced pluripotent stem cells with edited CCR5 loci grown in culture

Genetic engineering can make immune cells resistant to infection by human or monkey immunodeficiency viruses (HIV and SIV, respectively)

Worldwide, an estimated 37.

The HIV virus primarily infects and kills certain immune cells called T cells, gradually weakening a patient's immune system and increasing susceptibility to infections and certain cancers

Another approach to mass production of T cells is to create T cells from induced pluripotent stem cells (iPSCs)

Article title:

Generation of SIV-resistant T cells and macrophages from non-human primate-induced pluripotent stem cells with edited CCR5 sites

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