Synergy of Lidoca in combination with magnesium sulfate on postoperative pain in breast cancer patients: randomized, double-blind trials

Background and ObjectiveRecent use of intravenous complementary drugs, such as lidocarin and magnesium sulfate, has been increasingly used in multi-mode analgesiaHowever, an assessment of the effects of the combined use of the two drugs has not yet been reportedThe purpose of this study was to evaluate the role of intravenous drug use in reducing postoperative opioid use and pain scores in breast cancer patientsincluded 198 patients who underwent a mastectomy at the selected stageSeventy-eight people were excludedInfusion refentanyl (0.1 ug-kg-1)min-1), Lidocain (3 mg kg-1.h-1), magnesium sulfate (50 mg.kg-1h-15 mg-kg-1h-1) or Lidoca in addition to magnesium sulfateThe main results indicators were opioid consumption and pain scores during perioperative surgeryfruitLidocain group and magnesium sulfate group (n-30) had less afentanyl (P 0.001) and less than pyrethinandronetine and morphine after surgery (P 0.001)Only 2 patients (6.7%) of the Lidoca incharge with magnesium sulfate group require morphine (P 0.001)with acceptance of riffentani (n s 30; 76.6%, OR - 46.00, 95% confidence interval 8.69% to 243.25, P 0.001) and magnesium sulfate (n-30; 70%, OR32.66, 95% confidence interval 6.37% to 167.27, P 0.001) treated patients with a significant reduction in the number of patients who needed morphine after surgeryThe digital scores and speech scores in the first 24h of the Lidoca incharge magnesium sulfate group were lower than those of the other 3 groups (P 0.001)concluded lidocoin and magnesium sulfate had synergies in perioperative analgesia This may be another potential strategy for multi-mode analgesia original literature abstract
Mendon? A FT, Pellizzaro D, Grossi BJ, et, al Synergethofofofi-lidocaine and scarfate on peri-operative-after pain mastectomy a randomised, double-blind -blind strial .J Eur J Anaesiol 2020 Mar;37 (3) DOI: 10.1097/EJA.0000000000153 Recently, the use of venous adjuvants, such as lidocaine and sauiau, hasyn dweud However, no study has sevaluated the impact a combination of the two drugs OBJECTIVES To evaluate the ei eiacy of venous adjuvants in reducing opioid and pain scores after mastectomy DESIGN Randomised, double-blind, parallel-group, non--city clinical trial with a 1: 1: 1: 1 allocation ratio SETTING Hospital de Base do Distrito Federal, Brasilia, Federal District, Brazil from November 2014 to December 2017 PATIENTS One-hundred and wait-eight patients wereively scheduled for mastectomy Seventy-eight waswed INTERVENTIONS Intra-operative infusions of remifentanil (0.1mgk g-1min-1), lidocaine (3 mg kg-1h-1 carnage), sulfate (50 mg-1R15 mg kg-1h-1) or lido with saures sesss All patients received dh'e standard general anaesthesia MAIN OUTCOME STATS PERi-operative op op and pans RESULTS The Patients Who Ed Both Lidocaine and Sabansau sylwedd group (n-30) sconsumed dafentanil y surgery (P.001) and less dionepyr (P 0.001) and morphine (P.001) in the post Only two patients (6.7%) In the lidocaine and the scarfate group needed morphine (P 0.001) These requirements wasver dieweil yn bye by-year with patients who'r dweud remifentanil (n s30; 76.6%) and the sauerfate (n? 30; 70%; odds ratio 46.0, 95% confidence interval 8.69 to 243.25, P 0.001, and odds ratio 32.66, 95% sythy 6.37 to 167.27, P 0.001, respectively) The patients of the lidocaine and the sinois ssulfate group had slepnos in the first 24h postoperative yn ystyforth noun sydd the sydd sydd sydd sydd sydd sydd sydd by the postaes thesa theo sane care unit (P.001), 12 h (P.001) and 24 h CONCLUSION Ath aphhase a synergistic a synergeth of the use of both lidocaine and a tha iad a tha iad This may be tha indydd yn multimodal analgesia regimen anesthGH Source: Poppy