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Targeting Claudin 18.2 and 4-1BB!

 Last Update: 2021-04-19
 Source: Internet
 Author: User

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Source: Guanlan Pharmaceutical

On March 30th, Tianjing Bio and South Korea’s ABL Bio jointly announced that the bispecific antibody TJ-CD4B (also known as ABL111) that targets Claudin 18.

TJ-CD4B is an innovative bispecific antibody that simultaneously targets the tumor antigen claudin 18 splice 2 (Claudin 18.

Preclinical studies have shown that even in the case of low expression of Claudin 18.

This time, approved in the United States is a multi-center Phase 1 dose-climbing trial, which will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of TJ-CD4B in patients with advanced or metastatic solid tumors.

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