Tau protein misfolded this week's "Nature" cover story

Cover image: Yang Shi (Copyright: MRC Molecular Biology Laboratory) Cover Story The structure-based classification of tau protein diseases is generally believed to be able to firmly shape the skeleton of nerve cells, but in neurodegenerative diseases such as tau protein diseases, tau The protein will misfold and accumulate to form filaments
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In this issue of "Nature", Sjors Scheres, Michel Goedert and colleagues have identified various folds of tau protein filaments in diseases such as Alzheimer's disease based on their previous work
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They revealed four other folds related to specific diseases, including progressive supranuclear palsy and argyrophilia
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Subsequently, the researchers used these different folds to determine the hierarchical classification of tau protein diseases based on structure
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This classification complements clinical diagnosis and neuropathological anatomy, and can also be used to identify new disease entities
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The cover shows some tau protein filaments that have been discovered so far that are associated with specific diseases
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"Nature" paper: Structure-based classification of tauopathies long press and identify the QR code on the right, read the full text → related reading above and below ground | This week "Nature" cover story 3D electronic micro-aircraft | This week "Nature" cover story