The achievements of Liu Tao's team were selected as the top ten domestic medical science and technology news in 2021

On January 19, 2022, the top ten medical science and technology news in China and the top ten international medical science and technology news in 2021, organized by Health News, were announced

Liu Tao's team from Peking University School of Pharmacy and Ye Haifeng's team from East China Normal University School of Life Sciences jointly developed a gene "switch" that rapidly regulates insulin expression, providing a new tool for synthetic biology and cell therapy research

A cell therapy system based on gene codon expansion technology regulates insulin expression by oral administration of unnatural amino acids in mice

The study uses genetic codon expansion technology to design switches directly at the protein translation level, which can span the transcription process and rapidly produce insulin

Reasons for listing: The NATS system based on translational regulation has the advantage of rapidly regulating the expression of drug proteins, providing a new regulatory tool for the field of cell therapy, and an alternative to insulin injection therapy for diabetes in the future.

【Extended reading】

This medical science and technology news selection adopts a combination of data retrieval and expert and scholar discussion and evaluation, and sets up preliminary screening, preliminary evaluation and final evaluation

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【Introduction to Liu Tao】

He is currently the director of the Department of Molecular and Cellular Pharmacology, School of Pharmacy, Peking University, and PI
of the State Key Laboratory of Natural Medicines and Biomimetic Medicines .
Obtained the title of Overseas High-level Young Talent of the Organization Department of the CPC Central Committee, National Outstanding Youth , and Outstanding Youth of Beijing
.
He has published more than 40 research papers in well-known journals at home and abroad
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The research direction of the team includes the application of biotechnology in the research and development of biological drugs and the analysis of disease mechanism, and the development of innovative protein drugs containing unnatural amino acids, which are applied in various fields such as tumor and gene therapy, thus promoting the upgrading of biological drugs
.

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