The bacteria's peripheral spatial protease removes "IQ" to promote the level of anti-reversal stress of bacteria.

As a single-celled organism, Gram-negative bacteria monitor environmental signals mainly by using receptors on the lining of cells in the process of sensing external stimuli.
, the receptor histaline kinase completes the transmembrane transmission and signal transduction of environmental signals by protein reversible phosphating (phosphorylation-dephosphate), and plays a role similar to that of the central nervous system of higher animals, thus being known as the "IQ" of bacteria by scientists.
recently, the Qianwei Research Group of the Institute of Microbiology of the Chinese Academy of Sciences was the first in the world to discover that bacterial peripheral space proteases modify the bacteria's "IQ" in an irreversible and highly specific way to promote the level of bacterial resistance stress.
research "Proteolysis of histidine kinase vgrs inhibits its autophosphorylation and promots osmothitin Xanthomas campestris" published in the journal Nature Communications.
a receptor histanine kinase called VgrS plays a key role in the infection of plants with the pathogen bacteria, the wild rape jaundice bacteria.
the iron deficiency environment produced by the inherent immune response in the VgrS perceptive subject, and regulatethe process by which pathogenic bacteria compete for and absorb iron from the host.
, therefore, VgrS mutation strain or inactivation can lead to bacterial iron metabolism disorders and severe disease-causing decline (Wang et al, 2016. PLoS Developments).
However, VgrS has a two-sided function.
study found that when bacteria face high seepage stress, the activation of the VgrS signaling pathway can seriously hinder the growth of bacteria.
in order to rapidly quench the pathway, the protease Prc in the bacterial peripheral space binds to the signal-sensing region of VgrS at the end of the amino spectrum, and then specifically cuts the first 9 amino acids and inhibits the kinase activity of VgrS in a "snuffing and tailing" manner.
VgrS is inactivated by Prc-specific cutting is a prerequisite for bacteria to combat high seepage stress.
the study provides sufficient evidence in genetics, enzymatics and biophysics to demonstrate the importance of these processes for bacteria to adapt to a stressed environment. At the same time,
, the results also suggest that: the important receptors of pathogenic bacteria as molecular action drugs, in a specific living environment may improve the adaptability of bacteria, which must be more comprehensive and in-depth research. Deng Chaoying, an assistant researcher at the
Institute of Microbiology, and Zhang Huan, a doctoral student, are co-authors of the study.
research has received funding from the Chinese Academy of Sciences' Strategic Leading Science and Technology Special (Class B), the National Natural Science Foundation project and the National Key Laboratory of Plant Genomics. Gao Fu, Tao Yong and Wen Tingyi, researchers at the Institute of Microbiology at the
, have made valuable suggestions for protease cutting experiments.
Source: Institute of Microbiology.