 Home > Biochemistry News > Microbiology News > The cauliflower mosaic virus uses Arabidopsis RNA processing body components to serve it

The cauliflower mosaic virus uses Arabidopsis RNA processing body components to serve it

 Last Update: 2022-10-25
 Source: Internet
 Author: User

Tags

plant cell culture

rna amino acids

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Recently, Rudzka et al.
published online at The Plant Cell a report titled Arabidopsis RNA processing body components LSM1 and DCP5 aid in the evasion of translational repression during Cauliflower mosaic The scientific paper on virus infection discovered how cauliflower mosaic virus uses Arabidopsis RNA processing body components to evade translation inhibition
.

back

scenery

return

look at

Viruses are unique in that they are able to reuse and recycle host proteins and other components for their use
.
Cauliflower mosaic virus (CaMV) forms a special structure called a viral factory within host cells to promote efficient replication and evade defenses
.
The virus factory is made up of viral proteins, particles, and nucleic acids, but many host proteins and ribosomes are also assembled into these structures
.
Based on knowledge gained in the animal field, RNA particles, including stress particles and processors, are at the forefront
of viral disease regulation.
Several particle localization proteins directly interact with the virus and affect viral replication
.

section

learn

ask

title

We investigated the role of
processed body composition in CaMV infection.
We wanted to elucidate this interaction in two ways: how does CaMV infection affect the localization and abundance of processed body composition, and how do these proteins affect CaMV replication, especially the production of viral proteins?

grind

investigate

hair

appear

During CaMV infection, decapin DCP5 and LSM1 are localized to viral factories
.
In Arabidopsis dcp5 and lsm1 mutants, CaMV DNA and protein accumulation decreased, but RNA levels did not
.
We found that viral RNA was not a target for LSM1-mediated capping, and RNA stability was not compromised
in either mutant.
We examined dcp5 and lsm1 single mutants and their dual mutants with RNA-dependent RNA polymerase 6 (rdr6) and found that there were fewer
viral RNAs associated with ribosomes in single mutants rather than double mutants.
Thus, processed body proteins help the virus evade translation inhibition
of RDR6.

unfold

hope

not

come

It is unclear how RDR6 mediates translation inhibition of viral RNA in the absence of DCP5 or LSM1
.
Elucidating the role and exact mechanisms of viral factories and viral proteins in this interaction will help to further understand plant viral infection
.

References:

Gesa Hoffmann, Amir Mahboubi, Heinrich Bente, Damien Garcia, Johannes Hanson, Anders Hafrén, Arabidopsis RNA processing body components LSM1 and DCP5 aid in the evasion of translational repression during Cauliflower mosaic virus infection, The Plant Cell, Volume 34, Issue 8, August 2022, Pages 3128–3147, https://doi.
org/10.
1093/plcell/koac132

END

Gesa Hoffmann and Anders Hafrén

Translated by Chao Bian, TPC Assistant Features Editor

Edited by Xiaowen Shi, TPC Special Content Editor

Long press the QR code below to identify the following ***

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.