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The Chaer gene is the early key molecular switch that induces myocardial fertilization.
the latest research of Professor Li Hongliang of Cardiovascular Medicine at Wuhan University People's Hospital published online in nature medicine, a leading international journal.
the results of this new study by Professor Li Hongliang's team, it is the first time in the world that the chaer gene is missing, which can significantly inhibit the fertilization of myocardial cells induced by aortic stenosis surgery, reduce fibrosis cardiomyopathy reconstruction, and thus improve the blood function of the heart;
can effectively alleviate the deterioration of myocardial hypertrophy if it inhibits the expression of the Chaer gene.
this important original scientific research result provides a new theoretical basis for further elucidating the pathophysiological process esctic process of myocardial fertility and heart failure, and provides a new key molecular target for the clinical prevention and treatment of heart muscle fertility and heart failure.
, this major research results, Wuhan University People's Hospital Model Animal Center is another important scientific research output.
the center has established a systematic and perfect genetic ally technology and gene knockout technology platform, and independentresearch or co-development of genetically engineered mice more than 1000 strains, independent research and development of gene knockout rat more than 300 strains.
it is known that myocardial hypertrophy is an important pathological process of the development of major cardiovascular diseases such as hypertension and myocardial infarction, which shows the change of heart overload stress under the induced factors such as myocardial injury and vascular lesions. If
cannot intervene in its pathogenesis at an early stage, it will irreversibly induce pathological changes such as myocardial cell death, myocardial fibrosis, and eventually lead to cardiac dysfunction, heart failure and sudden cardiac death.
Source: Decoding Medicine.