The "earthquake" is coming? The Nobel Prize winner is suspected of falsifying 40 papers

2019 Nobel Laureate in Physiology or Medicine, Gregg L. Semenza, has been accused of academic misconduct.
as of the morning of October 20, the number of controversial papers exposed on Pubpeer, a well-known academic fraud site, had risen to 40, spaning 18 years. These papers were questioned about multiple use or picture PS, and a few articles were questioned about ethical issues.
Semenza probably wouldn't have won the Nobel Prize if this had been revealed two years earlier, " an industry scholar told China Science Daily. Another
said Semenza was likely to have only provided macro guidance on some of the studies and did not know the details of the work done by the following people.
"I said this, not to wash his land." But in such a scientific organization, in such a scientific ecology, a similar situation may be more common than we thought - it is extremely frightening. The researchers said.(anaphysiology) and Semenza, professors in the field of low-oxygen physiology in China, are collaborators and friends for many years.
, he received a WeChat article from a student saying that Semenza had been exposed to more than 30 papers, spanned 16 years.
" Semenza's earliest groundbreaking articles will be all right? "In shock, his first reaction was to worry that it would lead to a crisis in the whole field.
1990s, Semenza discovered and explored a series of work on hypooxygenated factor HIF-1, which is the cornerstone of the whole field. It can be said that without Semenza's findings on HIF, follow-up studies would not have been possible. Han Tong told China Science daily that Semenza's work is also called original in the Nobel Prize, which promotes originality.
if something goes wrong with these articles, it will be a major disaster for academia, " he said. Han tong said.
as of the morning of October 20, 40 papers on Symenza had been published on Pubpeer.
40 papers spanned 18 years from 2001 to 2018. Of these, 15 papers were published between 2013 and 2016, more than a third.
more than half of the papers on suspected fraud involving diseases such as breast cancer, coronary artery abnormalities, hypertension and erythroid hyperemia.of misfortune, Several of Hantong's most important papers, two "key works" published on the official website of the Nobel Prize, and the 1993 paper published in the Journal of Biochemistry, Actuation of hypoxia-inducible factor 1 and the DNA binding activity by hypoxia, were not faked.Semenza was exposed to academic fraud, many people recalled the shock of 31 papers being withdrawn in 2018 by
. The "c-kit-positive heart stem cells" "discovered" by Anversa may not exist. This incident has had a serious and far-reaching impact on the relevant research areas.
Chen Guang (a lithase), a scholar in the field of low-oxygen research, told China Science Daily that the big probability of problems with Semenza's paper would not have such an impact.
" Symenza's most important contribution was his discovery in the 1990s of a series of work on the low-oxygen inducing factor HIF-1, which was not included in the papers that were exposed to problems. In fact, the discovery of HIF-1 work is very solid, the existence of HIF-1 has been confirmed by a series of subsequent studies. Chen Guang said, "We see that most of the studies that are being questioned are studies that have been converted downstream." If
had happened two years earlier, Semenza probably would not have won the Nobel Prize. But even now that it has been revealed, there is a good chance that his Nobel Prize will not be withdrawn. "After all, the Nobel Prize has historically been awarded to completely wrong studies, wrong conclusions, but there is no precedent for withdrawal. The "'s "special attention" to Semenza continues, searching for his name on Pubpeer, which is updated every few hours.
, a well-known academic counterfeiter, has also joined the "Let's Find" campaign.
of the papers that were published on suspicion of fraud, the main problem is: 1. The most sick of the way: a picture multi-use or picture PS. the most frequently seen comment on "Much more similar than expected."
other images have been questioned about the use of PS
. 。 2. A few articles have also been questioned about ethical issues. the tumors of the laboratory mice here were questioned as being too large.
questions, as of the morning of October 20, two authors had responded to the comments.
is Semenza's co-author at Johns Hopkins University and co-author of one of the papers, Akrit Sodhi. 。 Sodhi first admitted that two images had been "unintentionally exchanged" but that "it is important that this is not the case with repeated images under different experimental conditions".
, he said, "this unintentional error does not affect the conclusions drawn from this particular experiment".
is also Semenza's collaborator, Rajv R Ratan of Cornell University's Weir School of Medicine. some of the pictures look almost the same, they're not the same picture, he says. "The people who did the work have been away from the lab for a long time, but we'll go back and see what happens."
addition, an article has been withdrawn. have been erragnosed or corrected. see that Semenza is either a communications writer or a co-author in these papers, " he said. He may not be directly involved in the front line, but he does need to be held accountable for it. Chen Guang said.
"You think, such a big man, he's not short of papers, he's not short of reputation, he's not short of money." Why did he fake it? So I think it's quite possible that he's just doing macro-guidance on some of the research and doesn't know the details of what the people are doing. "
" I said, not to wash his land. Chen Guang said, "But in such a way of scientific research organization, in such a scientific research ecology, similar situations may be more common than we thought - it is very frightening."
China Science Daily tried to ask Symenza's own opinion on the fraud allegations by e-mail, but as of the time of writing, it had not received a response from Semenza. 。 Semenza was born in New York in 1956 at the age of 64. In 1999, he became a full-time professor at Johns Hopkins University, where he has been Director of the Vascular Research Program at the Institute of Cell Engineering since 2003.
2019, Symenza won the Nobel Prize in Physiology or Medicine along with two other scientists, Ratcliffe and Kerin, for his "discovery in the mechanisms of cell perception and adaptation to oxygen changes."
the early 1990s, Semenza's lab discovered the low-oxygen induction factor HIF-1 and purified it in 1995. Since then, Ratcliffe and Kelin have discovered the degradation mechanism of HIF.
years, Semenza's main research focus is the relationship between HIF-1 and tumors, isohemia heart disease, coronary artery disease, chronic lung disease and other diseases.
he said in an interview with the media that he attaches great importance to "the transformation of scientific research results", hoping that his research results can go to the clinic, for the benefit of more patients.