The first Asian pig "ultra-clear" genome map has been released

assembly of the Phased genome of Luchuan pig chromosomes. Tang Zhonglin
Recently, BioRxiv published online a sequence of high-quality Phased genomes at the chromosome level of China's fine local pigs, Luchuan pigs. This not only fills the gap in the lack of high-quality reference genomes in Asian pigs, but also provides a new direction for genome assembly. The results were led by the pig genome design and breeding innovation team of the Shenzhen Agricultural Genome Research Institute (the "Genome Institute") of the Chinese Academy of Agricultural Sciences.
Zhonglin, a researcher at the Institute of Genomics and a researcher at the Institute of Genomics, told China Science that using a number of sequencing techniques and assembly algorithms, they have for the first time obtained two sets of chromosomal-level, complete genome sequences. This indicates that alloty genes from parents can be completely distinguished, which provides valuable data and technical basis for the study of the function of allegens, and has important theoretical and applied value.
species, including humans, are doubles. In other words, each bino-body individual has two sets of thyx sequences from different parent sources. In addition to a high degree of continuity, the pig genome we assembled succeeded in obtaining two chromosome-level genome sequences, the first of its kind in the field of genome assembly research. "This means that we can study both the variation of the omogeneic chromosome and the function of alleles from different parents. This is a long-awaited dream for scientists in genomics, and today we have taken a big step forward. According
, east and west pig species have their own independent domestication origin, belonging to two different evolutionary branches, and have obvious morphological and genetic differences. However, the current study of pig genomics uses the genome sequence of Duroc, a Western pig species, which in part limits the study of genomics in Asian pigs.
study shows that Luchuan and Dulock pigs split about 1.7 million years ago. By comparing the genomes of the two, they found that the 272 positive selection genes of Luchuan pig were significantly rich in protein tyrosine kinase activity, microtubule activity, GTPase activator activity and ubiquinin metastase activity, while Dulock pig positive selection gene was closely related to G protein coupled subject activity. This not only provides key baseline data for the field of pig genetics, but also opens up a new path for using pigs as model animals to study human health and disease.
Tang Zhonglin, China is the world's largest pig breeding and pork consumer, with one-third of the world's pig breeds. These resources are a genetic treasure trove of high-quality genes that dig deep into important traits such as local pork quality and disease resistance. However, with the popularity of commercial pig species in the West, local pig species have been hit very hard, some famous local species are rarer than giant pandas, and some species have even become extinct. The protection of local pig species resources is urgent, especially in the face of the challenges of African swine fever today, the release of the genome is of strategic importance.
the study was supported by key projects of the National Natural Science Foundation of China, major special projects on genetically modified organisms, the Shenzhen Science and Technology Commission and the innovation project of the Chinese Academy of Agricultural Sciences.
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