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The first CAR-T therapy targeting BCMA was approved by the FDA for marketing

 Last Update: 2021-04-19
 Source: Internet
 Author: User

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On March 26, Bristol-Myers Squibb and bluebird jointly announced that the FDA has approved Abecma (idecabtagenevicleucel; ide-cel) as the first targeted chimeric antigen receptor (CAR) T cell immunity targeting B cell maturation antigen (BCMA) Therapies are used to treat adult patients with relapsed or refractory multiple myeloma.

Multiple myeloma (MM) is a malignant disease in which clonal plasma cells proliferate abnormally.

BCMA is an extremely important B cell biomarker, which is widely present on the surface of MM cells.

The FDA approval is based on data from a key Phase II clinical study code-named KarMMa.

The results of the study showed that the overall response rate (ORR) of 100 patients with evaluable efficacy was 72% (95% CI: 62-81), and 28% of patients achieved strict complete remission (sCR, 95% CI: 19%-38) %).

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