The first clinical evidence of new crown impairment of male reproductive function showed significant changes in sex hormone levels.

The first clinical evidence of the reproductive function of males with new crown impairments: significantly altered levels of sex hormones provide the first clinical evidence of the effects of the new coronavirus on male sexual glands.
researchers again caution edifying the reproductive function of male patients of childbearing age. Zhang Ming, associate professor of reproductive medicine at Zhongnan Hospital in Wuhan University,
, and others recently uploaded a paper entitled "Single-center study on the effects of new crown infection on male sexual gland function" (Effect of SARS-CoV-2 infection pered male male gonadal function: A single-center-center-center-study) on this pre-printed website MedRxiv (not formally published).
study compared 81 newly crowned patients with childbearing age with 100 healthy men of similar age, found that the former had significantly higher serum progesterone (LH) and prostospheric levels, while the ratio of testosterone to follicle stimulators to LH decreased significantly.
LH is a glycoprotein gonadotropin secreted by dorinding pituitary cells that promotes the translation of cholesterol into sex hormones in gonad cells.
the authors of the paper, although the semen parameterise is a direct reflection of reproductive gland function, the changes in these indicators also provide the first indirect clinical evidence for the new crown attack testicular function.
disease-causing targets are well known, the target of the new coronavirus attack cells is the receptor angiotensin conversion enzyme II, referred to as ACE2.
this target doesn't just happen in the lungs.
in mid-February, The Urology Department of Suzhou Hospital affiliated with Nanjing Medical University, Yu Caibin, and other patients concerned about kidney dysfunction and even damage.
while verifying the high lying of the kidneys in the new crown targets, they also accidentally found that the protein and mRNA expression of such targets in the testes was almost the highest in the human body, including interstitial cells and vasectomy cells.
in late February, two researchers at the National Institutes of Health (NIH) also pointed out that the targets of the new coronavirus are mainly concentrated in the testicles of sperm cells, interstitial cells and supporting cells.
in theory, any cell with such a target is vulnerable to the new coronavirus.
also, because the blood testicular barrier does not completely isolate the virus, compared to bacterial infections that usually attack the attached testicles and sub-glands, the virus in the blood mainly attacks the testicles.
Zika, Ebola, Marburg virus, etc. have been found in male testicles and semen and cause sexual transmission.
HIV and mumps can also induce testicular inflammation and even infertility.
SARS, which has the same target as the new crown, has been found to cause testicularitis.
, the researchers speculated that the new crown infection may inhibit the cell's reproductive-related functions, resulting in a failure of sperm.
however, this hypothesis has not previously been clinically proven. The team of the Center for Reproductive Medicine at Central South Hospital, Wuhan University,
81 patients, reviewed serum samples from 81 male patients with new crowns.
they were admitted to Wuhan's Raytheon Mountain Hospital on March 5 and aged between 20 and 54 (median 38 years).
81 cases were "light" patients with no positive change in chest, 70 were diagnosed as "normal", i.e. have symptoms of common respiratory infections such as fever and cough, chest positive changes;
the basic data for 81 patients with new crowns in men, a total of 31 cases showed elevated serum alalanine transaminase (ALT) and/or serum domide transaminase (AST), indicating that the liver function impairment control group was randomly selected 100 healthy men of similar age and normal reproductive function.
the hormones tested include testosterone (T), estradiol (E2), progesterone (P), prolactin (PRL), progesterone (LH), follicle stimulator (FSH) and anti-miaole tube hormone (AMH).
changes in sex hormone levels increased significantly between lutein and prolarpentin levels in patients with new crowns, and significantly higher levels of testosterone and follicle stimulators compared to lutein.
researchers believe that while there was no significant change in testosterone levels, there was a subtle negative feedback mechanism for testosterone and LH.
early stages of hypothyroidism, impaired testosterone production may stimulate LH release, allowing testosterone levels to be temporarily maintained.
, the proportion of sex hormones, such as testosterone/LH, is better able to respond to male reproductive gland function.
the improvement of levels of the sex hormone sphylactic hormone in the experimental and control groups may lead to pituitary inhibition and reduced gonadotropin.
and there was no significant change in FSH levels, which support the hormone suppression of cells, suggesting that the new coronavirus may have less effect on supporting cells than interstitial cells.
to a combination, the authors suggest that an increase in LH and a decrease in the testosterone/LH ratio may be caused by testicular dysfunction, such as interstitial cell damage.
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