The first domestic mRNA vaccine is about to be approved, and the super antibody can neutralize a variety of coronaviruses. New crown research progresses in a week

Moderna vaccine protects against two variants of new crowns

Moderna vaccine protects against two variants of new crowns

Source: Nature

Source: Nature Source: Nature

On July 9, a study published in Nature evaluated the effectiveness of the Moderna vaccine against mutant strains of "Alpha" (B.

The results showed that two weeks after vaccination with two doses of Moderna vaccine, the effectiveness of preventing the infection of the "alpha" mutant strain can reach 100%; the effectiveness of preventing the infection of the "beta" mutant strain is 96.

Studies have pointed out that the protective efficacy of Moderna vaccine against the virus will be significantly improved after the third week of vaccination with the first dose, while the increase in the protective efficacy of the "beta" mutant strain is relatively slow, while the second dose of vaccine can provide Maximum protection

Multiple patients were infected with two variants of new crown at the same time

Multiple patients were infected with two variants of new crown at the same time

At the European Conference on Clinical Microbiology and Infectious Diseases on July 11, a case report submitted by the participating researchers stated that a 90-year-old man in Belgium was infected with both "Alpha" and "Beta" variants of the new crown virus

On the 12th, the Ministry of Health of Thailand pointed out that 7 infected people were infected with both the "Alpha" and "Delta" mutants of the new coronavirus.

Sinopharm and Kexing vaccine enter the vaccine library and can supply 110 million doses of vaccine

Sinopharm and Kexing vaccine enter the vaccine library and can supply 110 million doses of vaccine

Source: GAVI

Source: GAVI Source: GAVI

On July 12, the Global Alliance for Vaccines and Immunization (GAVI) announced that it had signed pre-purchase agreements with Sinopharm Group and Kexing, which means that Sinopharm vaccine and Kexing vaccine have entered the "New Coronary Pneumonia Vaccine Implementation Plan" (COVAX) vaccine library , And can start supplying vaccines to COVAX in July for the prevention and control of the new crown epidemic in developing countries

These two vaccines have entered the WHO emergency use list, and 110 million doses of the new crown vaccine can be supplied to COVAX by the end of October this year, and the follow-up supply will be long-term

Machine learning model can predict the severity of COVID-19

Machine learning model can predict the severity of COVID-19

Source: JAMA Network

Source: JAMA Network Source: JAMA Network

On July 13, a study published in the JAMA Network analyzed the risk factors of severe cases and tracked the progression of the disease over time

The researchers built a machine learning model using data from 34 medical centers from January to December last year, including more than 1 million adults (174,568 positive and 1,133,848 negative)

The analysis shows changes in treatment methods, confirms that patient survival rates have improved during 2020, and uses the collected data to establish a machine learning model to predict patients who will be seriously ill

Health and socio-economic factors affect the death rate of COVID-19

Health and socio-economic factors affect the death rate of COVID-19

Source: PLoS Medicine

Source: PLoS Medicine Source: PLoS Medicine

On July 13, a study published in the "PloS Medicine" (PLoS Medicine) showed that 43% of the new crown deaths in the United States are related to county-level socio-economic indicators and health vulnerabilities.

Researchers extracted county-level estimates of 14 indicators related to COVID-19 mortality from public data sources, modeled the proportion of county-level mortality explained by established health and socioeconomic indicators, and evaluated each The estimated effect of the predictor

The results estimate that for every thousand residents: for every 1% increase in the prevalence of chronic kidney disease, the death rate increases by 43%; for every 1% increase in the number of residents in nursing homes, the death toll increases by 39; the elderly (over 65 years old) may not have insurance For every 1% increase in the 18-64-year-old population, the death toll increased by 2.

The first domestic mRNA vaccine is about to be approved

The first domestic mRNA vaccine is about to be approved

Source of clinical data of BNT162b: NEJM

Source of clinical data of BNT162b : NEJM Source of clinical data of BNT162b: NEJM

On July 14, Fosun Pharma stated that the National Food and Drug Administration's review of the mRNA new crown vaccine "Fubitai" (BNT162b2) has basically been completed, and the expert review has been passed

The administrative approval stage is currently being stepped up.

New evidence for the safety of mixed vaccination

New evidence for the safety of mixed vaccination

Source: NEJM

Source: NEJM Source: NEJM

On July 14, a study published in the New England Journal of Medicine (NEJM) showed that mixed vaccination of adenovirus vector vaccine (ChAdOx1 nCoV-19) and mRNA vaccine mRNA-1273 produced antibodies with better neutralizing efficacy than vaccination Two doses of ChAdOx1 nCoV-19 vaccine

Researchers pointed out that mixing the mRNA-1273 vaccine 9-12 weeks after the initial ChAdOx1 vaccination can effectively further stimulate the new coronavirus-specific B cell memory, and the second injection of the mRNA-1273 vaccine may be harmful to B.
1.
351 Mutant strains provide better protection
.

This work is the first peer-reviewed paper officially published, adding new evidence for the immunogenicity and safety of mixed vaccination
.

Super antibodies can neutralize a variety of coronaviruses

Super antibodies can neutralize a variety of coronaviruses

Source: Nature

Source: Nature Source: Nature

In a work published in Nature on July 14, the research team isolated 12 kinds of antibodies from blood samples of people infected with the new coronavirus or other B-coronavirus branch B.
Among them, S2H97 showed It has a strong neutralizing ability and can be combined with the RBD of a variety of coronaviruses under laboratory conditions to prevent its cell-to-cell transmission, and can effectively protect hamsters from being infected by the new coronavirus
.

Further research also revealed that the target of S2H97 is a hidden domain, which is only visible when the virus binds to cell surface receptors.
This discovery may inspire the development of a variety of vaccines and therapies
.

Half of COVID-19 hospitalized patients have complications

Half of COVID-19 hospitalized patients have complications

Source: the Lancet

Source: the Lancet Source: the Lancet

On July 15, a study published in The Lancet reported on the complications of hospitalized patients with COVID-19
.

The study counted the relevant information of 80,338 inpatients from 302 British hospitals from January 17 to August 4 last year.
The average age was 71 years old and 56% were male
.
49.
7% of patients had at least one complication
.

The study found that the proportion of patients with complications in the end was very high, 24.
3% were renal complications, 18.
4% were respiratory complications, 16.
3% were systemic complications, and 4.
3% were neurological complications
.
In addition, men and patients over 60 years of age are most likely to have complications, and patients with previous underlying diseases are also more likely to have complications
.

Senescent cells in the body will increase the patient's condition

Senescent cells in the body will increase the patient's condition

Image source: Science

Picture source: Science Picture source: Science

On July 16, a study published in Science showed that the number of senescent cells in the body will affect the severity of the disease.
If these senescent cells are removed, the survival rate after infection with the new crown can be significantly improved
.

Researchers have discovered that after senescent cells are exposed to the pathogenic lipopolysaccharide and the S1 protein subunit of the new coronavirus, they secrete more aging-related molecules.
A similar phenomenon has been observed in old mouse models
.
Further analysis showed that among the secreted inflammatory molecules, IL-1α can reduce the expression of antiviral-related proteins and increase the expression of ACE2 receptors on non-senescent cells
.

Further research found that after infection with the mouse coronavirus, the marker molecules secreted by the senescent cells of the mice that received anti-aging drugs were significantly reduced, the survival rate of the mice was significantly higher, and the antibody response to the mouse coronavirus was also somewhat different.
Enhanced
.

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