The first sound pharmaceutical industry introduced a new class of drugs approved clinically for gyration with high uric acidemia

Screenshot Source: CDE official website gyro is a common metabolic disease, is monosodium urate (MSU) deposition caused by crystal-related joint disease, and is directly related to metabolic disorders and/or uric acid excretion caused by high uric acidemia.
URAT1 selective inhibitor is a new glycour treatment drug in study, which effectively controls blood uric acid levels by selectively inhibiting URT1 re-absorption of uric acid and increasing uric acid excretion.
according to a synth pharmaceutical press release, there is currently no UAT1 highly selective inhibitor approved in China.
SIM1909-13 tablet is a highly selective inhibitor of URT1, which excludes the selective inhibition of OAT1/3 proteins and may help improve its safety.
preclinical data show that SIM1909-13 tablets have significant efficacy and that liver and kidney side effects may be lower.
in a randomized, double-blind, placebo-controlled Phase 1 study, the researchers assessed the safety and tolerance of SIM1909-13 tablets.
the clinical trial included more than 50 subjects.
results show that SIM1909-13 tablets have the effect of significantly reducing blood uric acid levels in the dose range of 3-10 mg, and have good safety and dose dependence characteristics.
, SIM1909-13 tablets are currently conducting Phase 2b clinical trials in Korea and have shown good clinical efficacy and safety.
can be associated with kidney lesions, serious joint damage, kidney damage, often accompanied by hyperlipidemia, hypertension, diabetes, arteriosclerosis and coronary heart disease.
according to the press release, the prevalence of gout in China is also on the rise, with about 32 million patients, became China's second largest metabolic disease.
: The Drug Review Center (CDE) of the State Drug Administration of China. Retrieved Nov 19, 2020, from the first sound pharmaceutical gyration with high uric acidemia treatment drug SIM1909-13 tablets by clinical trials implied permission . Retrieved Nov 19, 2020, from Source: Medical Mission Hills