The growth restriction or deletion of embryos can secrete the growth factor CD49a,Eomes-NK cell subgroups.

In the course of embryonic development, a special mother-fetal interface is needed to protect the normal development of the fetus.
the mother-fetal interface includes a large number of metamorphosis natural killer cells (dNK), which account for 70% of the total number of lymphocytes in the first trimester of pregnancy, and it is not clear what role such a large number of dNK cells play in embryonic development.
recently, Wei Haiming, a professor at the Institute of Immunology of the Chinese University of Science and Technology, and Tian Zhigang, a team of researchers, found that a large number of CD49a-Eomes-NK cell subgroups exist locally in human and mouse early pregnancy metamorphosis tissue, which promotes the development of embryos by secreting growth factors.
the absence of nk cells, which secrete growth factors, there is a limit to embryonic growth.
published in Immunity on December 19.
embryo development is limited and recurrent abortion is a clinically common pregnancy-related disease, and is closely related to the microenvironment abnormality of the mother's immune system.
the team compared the functional genetic differences between metamorphosis NK cells and peripheral blood NK cells through whole gene screening, and found that the high expression of PTN and OGN in early pregnancy metamorphosis was very important for early embryonic development.
the hlA-G interaction with metamorphosis NK cells expressed by the fluff-derived extra-fed layer cells from the embryo source, inducing NK cells to express growth factors in large numbers and promoting embryonic development.
found significantly less metamorphosis NK cells in patients with recurrent miscarriages to express growth factors and were unable to support the normal development of early embryos.
in the study of mouse pregnancy models, it was found that Nfil3 transcription factors are very important to protect the function of CD49a-Eomes-NK cell subgroups.
the absence of the transcription factor, the mouse mother-fetal interface NK cells were greatly reduced, and the intrauterine embryo had severe growth restrictions.
in addition, the study found that the incidence of abortion and limited embryo growth during pregnancy is higher, and the mechanism of studying the mechanism was studied by using the model of aged mice, and found that although the number of NK cells in aged mice did not change much, the ability to secrete growth factors was significantly reduced.
in order to save the embryo growth restriction caused by the reduction of NK cell secretion growth factor, the team induced metamorphosis-like NK cells in vitro with bone marrow hematopoietic stem cells, and conducted intravenous transmission therapy in mice, and the pregnancy outcome of aged mice and growth factor defects improved significantly, and embryo growth was restricted.
the study found that NK cells have unique physiological functions to promote embryonic development in the metamorphosis tissue, and explored the targeted induced specific function NK cell transmission protocol, which provides new ideas for clinical treatment of such related diseases such as embryo growth limitation and recurrent abortion.
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