The human brain changes before becoming obese

With the development of the economy and the improvement of living standards, obesity has become a major public health problem worldwide

In fact, obesity is a disease

On November 2, 2021, researchers from the University of Turku in Finland published a research paper in the International Journal of Obesity

This study shows that before a person becomes obese, the function of the neural network in his brain that regulates satiety and appetite has changed

Obesity is related to changes in brain insulin sensitivity and neurotransmitter function

The research team used positron emission tomography (PET imaging, positron emission tomography) to study the functions of insulin, opioids, cannabinoids, etc.

The results showed that participants with a higher risk of obesity (parents with obesity or type 2 diabetes) had changes in insulin signals in the brain, and insulin-stimulated brain glucose uptake increased overall

The influence of obesity risk factors on brain function

Tatu Kantonen, the corresponding author of the study, said these findings indicate that before a person becomes obese, disorders of the brain's neural network that controls satiety and appetite can be observed.

These results may have an impact on the development of obesity prevention interventions, indicating that the brain and central nervous system are important targets for obesity treatment

Generally speaking, people who have obvious risk factors for obesity (parental obesity or type 2 diabetes) but have not yet developed obesity have changes in the insulin sensitivity of the brain and the signals of opioids and endocannabinoids

These changes in the brain's neural network emphasize the genetic and centrally mediated mechanisms in the development of obesity

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