The importance of gut microbiomes deserves to be emphasized over and over again, as it is the engine that drives human health.

believe that people are no longer unfamiliar with the intestinal bacteria, more than a decade ago, we know very little about the gut bacteria, because most gut microorganisms can not be cultured in-body, so we have no way to study them. We all know they exist, but there is no way to get any information about them. At the time, however, we weren't worried because at the time we thought bacteria were just passers-by in the gut, just coming together, and they would excrete with faeces, which doesn't necessarily play an important role in our health.with the development of science and technology, the situation has changed dramatically, we have broken through the limitations of traditional culture technology, so that we can open up the layers of intestinal bacteria fog. The barriers to research have been removed, and our understanding of gut bacteria is exploding.a very complex microbiome living in our gut, containing at least five types of microorganisms, including bacteria, fungi, viruses, parasites and ancient bacteria.bacteria are a single-celled organism, and most of us seem to talk about bacterial color change. It's true that some bacteria, such as Syriza or salmonella, are harmful and can cause us problems, but in fact most bacteria are good and have been trying to help us, most of them are good friends.fungi are both single-celled and multi-celled, similar to animals and plants, and have nucleus and other cytogenes. They are more complex than bacteria, but like bacteria, they are often considered harmful, but there are many fungi that are also trying to help us. They also compete with bacteria, meaning there is a zero-sum game in which one side gains and the other suffers.viruses are tiny particles of DNA or RNA that have no cells at all and are even considered inanimate. When we think of viruses, the first thing that comes to mind is often diseases such as influenza, AIDS and hepatitis B, including the new coronavirus now, but not all viruses are trying to harm humans. In fact, most viruses are an important part of a healthy and balanced gut microbiome and are necessary to maintain a harmonious balance of bacteria.parasites are nature's "thieves". They steal energy from the host and offer no benefit and try to be as erredgy as possible. There are many kinds of parasites, but most of them have become rare due to improvements in modern sanitation. Of course, we also have a lot of people who may be infected with some kind of parasite, but without any symptoms.ends up with ancient bacteria. Four billion years ago, before oxygen appeared, these ancient creatures were already on our planet, and we could find them in rift valleys or volcanoes deep in the ocean. We will also find them comfortable in our colons. We're just getting to know them, and they don't seem to compete with bacteria and fungi for energy, so they're not as susceptible to dietary regulation as the rest of our gut microbiome.the depth of the gut microbiome is elusive, and it is estimated that our gut microbes far outnumber the number of human cells themselves, which is an astronomical number, most of which are bacteria.may sound a little disgusting, but they're vital to our health. We are not just one person, but a superbiome of trillions of microorganisms.human gut, like the Amazon rainforest, is a complex ecosystem that thrives in balance and harmony. In the Amazon rainforest, all animals, plants and microorganisms are interdependent, and they are vital to this harmonious balance, and of course there are some species we hate, but they are essential, and their absence can have unintended consequences that undermine the health of ecosystems. That is why biodiversity is critical to any ecosystem.human gut bacteria are no exception, and species diversity is critical to their healthy balance. There are more than 1,000 bacteria living in our guts that are closely related to digestive function. They help us break down food and get the nutrients we need.our food is also the food of gut microbes, they also need food to provide energy for them, but not every microbe eats the same food. Every dietary choice we make encourages a particular group of microbes, while others may die out. If we permanently remove a food, microbes that depend on it for growth and reproduction may starve to death. They multiply so fast that within 24 hours of a change in diet, the composition of the gut bacteria changes. We can regulate the composition of our gut bacteria by controlling our diet.the food we eat is metabolized by gut microbes, and in most cases healthy gut bacteria reward us by metabolizeing food into something that reduces inflammation, promotes health and balance. But instead, unhealthy foods feed unhealthy microbes, which can punish us by making compounds that inflam the body.things we put in our mouths are metabolized by these microbes, including drugs. It also helps explain why the same drug works for one person and may be ineffective or even life-threatening for another. For example, the chemotherapy drug cyclophosphamide is actually activated by gut microbes, and the healthier the intestine, the better it will be to fight cancer.'t the only place we depend on them. Most importantly, their health effects extend far beyond the intestines themselves. To define human health as a whole, there should be five basic elements - immunity, metabolism, hormone balance, cognition, and gene expression - that cover all the foundations we need to survive as human beings, and gut microbiotics are closely linked to all five elements of human health. The gut microbiome is the command center of human health, and what happens in all parts of the body is usually dependent on the work of gut microbes, including the heart and brain.we can think of the gut as a factory of workers in many different roles. Each worker has his or her own expertise, and for the development of the factory, we need to make the most of our expertise. When workers in different positions do their jobs and cooperate with each other, the factory can operate healthy and normally. "However, if the division of labour is unclear (e.g. the engineer's work is done by sales), or if all the work is done by the same person, it is difficult for the plant to function properly.", when our gut microbiomes lack diversity, the five elements of human health (immunity, metabolism, hormone balance, cognition, and gene expression) may go wrong. They are all interconnected, but at their core are our gut bacteria.intestinal microbiome imbalance is the destruction of the balance of the intestinal bacteria, which is manifested in a decrease in the diversity of the intestinal bacteria, a significant reduction in beneficial microorganisms, and an increase in the abnormality of harmful microorganisms that promote inflammation. This is problematic, the intestines are no longer protected by anti-inflammatory beneficial bacteria, coupled with a large number of anti-inflammatory harmful bacteria, which will lead to the integrity of the intestinal wall to maintain a close connection to be destroyed, increased intestinal permeability, which is known as "intestinal leakage", which can lead to bacterial endotoxins into the bloodstream, causing systemic inflammation.bacterial endotoxins are produced by harmful bacteria such as E. coli and salmonella, which can trigger inflammation, from low inflammation to life-threatening sepsis, shock and multiple organ failure. Bacterial endotoxinemia is associated with many chronic diseases, including autoimmune diseases, obesity, heart disease, type 2 diabetes, fatty liver disease, osteoarthritis, depression, anxiety, Alzheimer's disease, and so on.sounds terrible, but don't worry, we have a way to beat it. For example, Thyrobacteria, a pathogenic bacteria that is also found in the intestines of healthy people, may be familiar to all. Under normal circumstances, healthy gut bacteria can inhibit the growth and reproduction of Thyrobacteria., however, if the intestines are damaged and there are not enough beneficial bacteria, Thyrobacteria can multiply and become stronger, leading to colitis, accompanied by abdominal pain, fever and severe diarrhea. This may even develop into sepsis, which quickly takes away the healthiest lives. In this case, emergency surgery may be required to remove the entire colon to get rid of the infection and save the patient's life.the beginning of the 21st century, difficult Thyrobacteria was usually found only in inpatients taking antibiotics. Antibiotics kill harmful bacteria as well as beneficial bacteria in large numbers, allowing antibiotic-resistant Thyrobacter difficile to multiply and dominate. Another, more powerful antibiotic is usually used at this time to treat Thyrobacter difficile infections. This approach worked for some time, but by 2010 or so we were seeing more and more cases of antibiotic failure. At the same time, we have seen the beginning of the presence of difficult Thyrobacteria in young people who have never taken antibiotics or been in hospital. As the effectiveness of antibiotics wanes, people become increasingly helpless with Thyrobacter difficile infections, with some people needing long-term antibiotic treatment and, more unfortunately, many losing their colons and even their lives.desperate, researchers tried to treat feces with feces, which is fecal transplants. When researchers transfer a healthy person's faeces to a patient's intestines, it's a miracle that it's effective in treating Thyrobacteria infections, which can be as effective as more than 90 percent.so what makes fecal transplants so special? Quite simply, it's about restoring the balance of the gut bacteria and getting the right bacteria back to work, and they immediately control and suppress pathogenic Tracylobacteria, which, like those with healthy gut microbiotics, may have difficult tract implants but do not cause infection. Fecal transplants are now also being used to treat many incurable diseases, with encouraging results.might ask, isn't feces food a digested waste? In fact, 60% of the weight of feces is actually bacteria, both good and bad bacteria, which reflect the bacteria in our gut. Even if you fast, we still produce feces because our gut bacteria are constantly replicating and updating.balance is essential for the gut microbiotics and the various parts of the body with which they communicate. We've been trying to get rid of bad bacteria for years, but maybe what we really should do is give the good bacteria the power to overpower the bad bacteria and dominate. When we reach equilibrium, our gut bacteria take good care of us. Our gut microbes are so powerful that even if they exist in the form of "waste", they can help cure people at risk.Intestinal bacteribus are the engines that drive human health, and instead of trying to eliminate bad bacteria, let's work together to empower good bacteria, restore the balance of the intestinal bacteribus command center, and allow trillions of small bacterial partners to naturally enhance our immune system, metabolism, hormone balance, cognitive ability, and gene expression to maintain our health."
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