The important role of potential imprinting control regions in mouse early embryonic development

During mammalian development, epigenetic modifications such as DNA methylation and histone modifications undergo different patterns of reprogramming in the parental genome .

On April 28 , 2022 , Professor Zhang Yong from the School of Life Science and Technology of Tongji University and Professor Gao Shaorong's research group published an online publication in Nature Cell Biology entitled Allele - specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential A research paper on imprinting control regions in pre-implantation embryo , reporting that H3K9me3 is required for the maintenance of DNA methylation during mouse preimplantation embryo development , and identified 2 in CpG -enriched regions co-marked by H3K9me3 and DNA methylation 2 potential imprint control areas .

Gao Shaorong /Zhang Yong collaborated in recent years to reveal the establishment process and regularity of H3K4me3, H3K27me3, H3K9me3 and nucleosome positioning during early embryonic development in mice [ ^{1-3 ]} .

To explore differences in CHMs between parents at high resolution, we generated single-parent H 3K9 me 3 and DNA methylation data in parthenogenetic and parthenogenetic embryos , identifying 1,2 79 parent- specific CHMs ( asCHM ), which includes 19 known ICRs .

Further, the researchers established a parent-specific regulatory function prediction system and identified 22 ICR - like regions ( ICRLRs ) from asCHM .

Figure 1 ICRLR functional verification 

Yang Hui, a doctoral student in Professor Zhang Yong's laboratory, Bo Dandan, Dr.

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